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Webinar: Probing antibody-target interactions in living systems

From: Rebecca Baillie <rbaillie>
Date: Thu, 9 Sep 2021 19:57:34 +0000

Probing antibody-target interactions in living systems
Yanguang (Carter) Cao, PhD., Assistant Professor, University of North Carol=
ina at Chapel Hill
September 15, 2021, 9:00-10:00 AM PDT
Register for free at https://www.rosaandco.com/webinars

Abstract:
Antibodies have become an attractive class of therapeutic agents for multip=
le types of diseases, mainly owing to their high target selectivity and tar=
get affinity. The target binding properties are critical for antibodies' ef=
ficacy and toxicity. However, we still heavily rely on the static in vitro =
system to characterize antibody's target binding properties, and their beha=
viors in vivo - the actual sites of actions - remain undefined. Our group h=
as developed a bioluminescence resonance energy transfer (BRET) imaging app=
roach that directly supports the measurement of the binding dynamics betwee=
n antibodies and their targets in the native tissue environment. Built upon=
 the imaging data, we have developed a spatially resolved computational mod=
el analyzing the longitudinal BRET imaging data to explore the kinetics of =
antibody-target binding. Our work has yielded insights into the physiologic=
al factors affecting antibody-target interactions in their sites of action,=
 which are critical for improving antibody-based therapeutics.


Received on Thu Sep 09 2021 - 15:57:34 EDT

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