NONMEM Users Network Archive

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Re: Problem with PSN4. 9 - COVARIANCE STEP ABORTED

From: Shankar Lanke <shankarlanke>
Date: Tue, 4 May 2021 10:25:10 -0400

Dear Rikard,
The version and option info are similar with the exception of PsN. Both
runs use the exact same options, version of NONMEM. Same PC, OS: located on
the linux server. But as Jakob mentioned, I will check with IT if there is
any change in Configuration of PsN.
Thank you very much, thank you all for your support.

EX:
PsN version: 4.4.8
Run started: ---
version_and_option_info.txt is overwitten if the run is restarted later
using option -directory.
The original file from the first call is saved as
original_version_and_option_info.txt.

Command:
/opt/scp/software/psn/4.4.8-foss-2017a-gfortran-5.2/bin/execute runXYZ.mod
-dir=runXYZ -nm_output=shk,ext,cov,cor,coi,phi,log.xml -clean=3
-parafile=parafile-62545143.pnm

NONMEM:
/opt/scp/software/nonmem-standard/7.3.0-foss-2017a-gfortran-5.2


On Tue, May 4, 2021 at 2:50 AM Rikard Nordgren <
rikard.nordgren

> Dear Shankar Lanke,
>
> PsN execute should in most situations be the same as running nmfe
> directly. You can check the model code at the start of the lst-files from
> either run to see which model was actually run by NONMEM. If there are no
> differences between these models I would check the settings in
> version_and_option_info.txt Did both runs use the exact same options,
> version of NONMEM etc? Did you run with the same version of the fortran
> compiler for example? Did you run on the same computer with the same
> operating system?
>
> Best regards,
> Rikard Nordgren
>
>
> On 2021-05-03 18:45, Shankar Lanke wrote:
>
> Dear NMUsers,
>
> I am having trouble with PSN4.9, if anyone has a similar issue may I know
> how to fix it?
>
> I ran a model that was developed prior to the release of PSN4.9. In PSN4.=
9
> the covariance step is aborted because S Matrix is unobtainable. I purged
> 4.9 and loaded 4.8, the model ran perfectly and matched the
> previous results. Thank you very much in advance.
>
>
>
> *Version 4.9*
>
> #TERE:
>
> Elapsed estimation time in seconds: 633.22
>
> 0S MATRIX UNOBTAINABLE
>
> 0COVARIANCE STEP ABORTED
>
> Elapsed covariance time in seconds: 47.98
>
> Elapsed postprocess time in seconds: 51.79
>
>
>
> *Version 4.8*
>
> #TERM:
>
> 0MINIMIZATION SUCCESSFUL
>
> NO. OF FUNCTION EVALUATIONS USED: 783
>
> NO. OF SIG. DIGITS IN FINAL EST.: 2.0
>
>
>
> Regards,
>
> Shankar Lanke
>
>
> --
> Rikard Nordgren
> Systems developer
>
> Department of Pharmacy
> Faculty of Pharmacy
> Uppsala University
> Box 591
> 75124 Uppsala
>
> Phone: +46 18 4714308www.farmbio.uu.se/research/researchgroups/pharmacome=
trics/
>
>
>
>
>
>
>
>
>
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--
Regards,
Shankar Lanke Ph.D.

Received on Tue May 04 2021 - 10:25:10 EDT

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