NONMEM Users Network Archive

Hosted by Cognigen

Re: Problem with PSN4. 9 - COVARIANCE STEP ABORTED

From: Shankar Lanke <shankarlanke>
Date: Tue, 4 May 2021 10:02:27 -0400

Dear Jakob,

   1. Did you run both PsN versions using the same nonmem version? *Yes*
   2. If termination was not successful, was PsN (execute) set up to try
   again with another set of initial estimates *[Yes, tried with different
   IEs, Fixed few, all combinations]*, and if it was: did you use the same
   seed when running execute-4.8 and execute-4.9? *Yes*
   3. ’sdiff -s’ to compare this file between the two runs =
with execute-
   *Yes*
   4. Did you change anything else in the configuration of PsN or NONMEM,
   e.g. the compiler? *Computing system is located in Linux server, I dont
   think if IT makes any changes to it without informing us, but I will che=
ck
   with them. *

Thank you so much for your time and input.


On Tue, May 4, 2021 at 8:58 AM Jakob Ribbing <jakob.ribbing
>
wrote:

> Dear Shankar,
>
> I think you will need to go deeper into the configuration and settings, a=
s
> well as to the directories where NONMEM was actually run, to answer this
> question.
>
> Here are some things that you can consider:
>
> - Did you run both PsN versions using the same nonmem version?
> - If termination was not successful, was PsN (execute) set up to try
> again with another set of initial estimates, and if it was: did you us=
e the
> same seed when running execute-4.8 and execute-4.9?
> - The control streams created by PsN (located in the NM_run1
> directory): are they identical? In this directory you will find e.g.
> psn.mod. If on a LINUX system you can just run diff or ’sdiff =
-s’ to
> compare this file between the two runs with execute
> - Did you change anything else in the configuration of PsN or NONMEM,
> e.g. the compiler?
>
>
> Best wishes
>
> Jakob
>
>
>
> Jakob Ribbing, Ph.D.
>
> Senior Consultant, Pharmetheus AB
>
>
> Cell/Mobile: +46 (0)70 514 33 77
>
> Jakob.Ribbing
>
> www.pharmetheus.com
>
> Phone, Office: +46 (0)18 513 328
>
> Uppsala Science Park, Dag Hammarskjölds väg 36B
> SE-752 37 Uppsala, Sweden
>
>
>
>
> On 3 May 2021, at 18:45, Shankar Lanke <shankarlanke
>
> Dear NMUsers,
> I am having trouble with PSN4.9, if anyone has a similar issue may I know
> how to fix it?
> I ran a model that was developed prior to the release of PSN4.9. In PSN4.=
9
> the covariance step is aborted because S Matrix is unobtainable. I purged
> 4.9 and loaded 4.8, the model ran perfectly and matched the
> previous results. Thank you very much in advance.
>
>
> *Version 4.9*
> #TERE:
> Elapsed estimation time in seconds: 633.22
> 0S MATRIX UNOBTAINABLE
> 0COVARIANCE STEP ABORTED
> Elapsed covariance time in seconds: 47.98
> Elapsed postprocess time in seconds: 51.79
>
>
> *Version 4.8*
> #TERM:
> 0MINIMIZATION SUCCESSFUL
> NO. OF FUNCTION EVALUATIONS USED: 783
> NO. OF SIG. DIGITS IN FINAL EST.: 2.0
>
>
> Regards,
> Shankar Lanke
>
>
>
> *This communication is confidential and is only intended for the use of
> the individual or entity to which it is directed. It may contain
> information that is privileged and exempt from disclosure under applicabl=
e
> law. If you are not the intended recipient please notify us immediately.
> Please do not copy it or disclose its contents to any other person.*
>


--
Regards,
Shankar Lanke Ph.D.

Received on Tue May 04 2021 - 10:02:27 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.