NONMEM Users Network Archive

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Re: Problem with PSN4. 9 - COVARIANCE STEP ABORTED

From: Jakob Ribbing <jakob.ribbing>
Date: Tue, 4 May 2021 14:58:38 +0200

Dear Shankar,

I think you will need to go deeper into the configuration and settings, as =
well as to the directories where NONMEM was actually run, to answer this qu=
estion.

Here are some things that you can consider:
Did you run both PsN versions using the same nonmem version?
If termination was not successful, was PsN (execute) set up to try again wi=
th another set of initial estimates, and if it was: did you use the same se=
ed when running execute-4.8 and execute-4.9?
The control streams created by PsN (located in the NM_run1 directory): are =
they identical? In this directory you will find e.g. psn.mod. If on a LINUX=
 system you can just run diff or ’sdiff -s’ to compare this=
 file between the two runs with execute
Did you change anything else in the configuration of PsN or NONMEM, e.g. th=
e compiler?

Best wishes

Jakob



Jakob Ribbing, Ph.D.

Senior Consultant, Pharmetheus AB


Cell/Mobile: +46 (0)70 514 33 77

Jakob.Ribbing

www.pharmetheus.com

Phone, Office: +46 (0)18 513 328

Uppsala Science Park, Dag Hammarskjölds väg 36B
SE-752 37 Uppsala, Sweden




> On 3 May 2021, at 18:45, Shankar Lanke <shankarlanke
>
> Dear NMUsers,
> I am having trouble with PSN4.9, if anyone has a similar issue may I know=
 how to fix it?
> I ran a model that was developed prior to the release of PSN4.9. In PSN4.=
9 the covariance step is aborted because S Matrix is unobtainable. I purged=
 4.9 and loaded 4.8, the model ran perfectly and matched the previous resul=
ts. Thank you very much in advance.
>
> Version 4.9
> #TERE:
> Elapsed estimation time in seconds: 633.22
> 0S MATRIX UNOBTAINABLE
> 0COVARIANCE STEP ABORTED
> Elapsed covariance time in seconds: 47.98
> Elapsed postprocess time in seconds: 51.79
>
> Version 4.8
> #TERM:
> 0MINIMIZATION SUCCESSFUL
> NO. OF FUNCTION EVALUATIONS USED: 783
> NO. OF SIG. DIGITS IN FINAL EST.: 2.0
>
> Regards, <>
> Shankar Lanke


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Received on Tue May 04 2021 - 08:58:38 EDT

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