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Re: Statistical power computation based on the wald test

From: Jakob Ribbing <jakob.ribbing>
Date: Mon, 22 Mar 2021 14:42:27 +0100

Dear Hammami,

Do you mean starting from a so-called full (pre-specified) model, and =
approximate which covariates in the nonmem model would reach statistical =
See the publication by Kowalski: =

Best regards


Jakob Ribbing, Ph.D.

Senior Consultant, Pharmetheus AB

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> On 22 Mar 2021, at 14:22, Hammami, Ibtihel /FR =
> Hi,
> We would like to compute a covariate inclusion statistical power =
based on the Wald test and using SE given by the fisher information =
> Is there any method to implement this directly in NONMEM or is there =
at least a way to output the Fisher Information matrix in NONMEM?
> Thank you.

Received on Mon Mar 22 2021 - 09:42:27 EDT

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