NONMEM Users Network Archive

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Re: computation of exponential error model for RUV

From: Jakob Ribbing <jakob.ribbing>
Date: Mon, 19 Jul 2021 18:20:26 +0200

Dear all,

For simulation, the EXP(EPS(1)) would be a log-normal distribution as inten=
ded, so either or would work in simulation mode and it is only in estimatio=
n (FOCE) the log-transform is necessary.



> On 19 Jul 2021, at 18:10, Leonid Gibiansky <lgibiansky
> yes, it does at estimation, not sure about simulations step.
> If you need true exponential error, log-transform of DV and model predict=
ions is needed
> Leonid
> On 7/19/2021 11:34 AM, Guidi Monia wrote:
>> Dear colleagues,
>> We would like to compare the NONMEM predictions with those obtained by a=
 Bayesian TDM software for models describing the residual unexplained varia=
bility with exponential errors.
>> We need to know if NONMEM performs a first order Taylor expansion of the=
 exponential error when data are fitted by the FOCE method:
>> Y=F*EXP(EPS(1)) -> Y= F*(1+EPS(1)).
>> Could someone help with this?
>> Thanks in advance
>> Monia
>> Monia Guidi, PhD
>> Pharmacometrician
>> Service of Clinical Pharmacology | University Hospital and University of=
>> Center of research and innovation in Clinical Pharmaceutical Sciences | =
University Hospital and University of Lausanne
>> BU17 01/193
>> CH-1011 Lausanne
>> email: monia.guidi
>> tel: +41 21 314 38 97
>> *CHUV**
>> **_centre hospitalier universitaire vaudois_*
>> /var/folders/mv/mxzxwndj1w761kc51dsd0hdm0000gp/T/

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Received on Mon Jul 19 2021 - 12:20:26 EDT

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