NONMEM Users Network Archive

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Re: computation of exponential error model for RUV

From: Leonid Gibiansky <lgibiansky>
Date: Mon, 19 Jul 2021 12:10:25 -0400

yes, it does at estimation, not sure about simulations step.
If you need true exponential error, log-transform of DV and model
predictions is needed
Leonid



On 7/19/2021 11:34 AM, Guidi Monia wrote:
> Dear colleagues,
>
> We would like to compare the NONMEM predictions with those obtained by a
> Bayesian TDM software for models describing the residual unexplained
> variability with exponential errors.
>
> We need to know if NONMEM performs a first order Taylor expansion of the
> exponential error when data are fitted by the FOCE method:
>
> Y=F*EXP(EPS(1)) -> Y= F*(1+EPS(1)).
>
> Could someone help with this?
>
> Thanks in advance
>
> Monia
>
> Monia Guidi, PhD
>
> Pharmacometrician
>
> Service of Clinical Pharmacology | University Hospital and University of
> Lausanne
>
> Center of research and innovation in Clinical Pharmaceutical Sciences |
> University Hospital and University of Lausanne
>
> BU17 01/193
>
> CH-1011 Lausanne
>
> email: monia.guidi
>
> tel: +41 21 314 38 97
>
> *CHUV**
> **_centre hospitalier universitaire vaudois_*
>
> /var/folders/mv/mxzxwndj1w761kc51dsd0hdm0000gp/T/com.microsoft.Outlook/WebArchiveCopyPasteTempFiles/cidimage001.png
>
Received on Mon Jul 19 2021 - 12:10:25 EDT

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