NONMEM Users Network Archive

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computation of exponential error model for RUV

From: Guidi Monia <Monia.Guidi>
Date: Mon, 19 Jul 2021 15:34:06 +0000

Dear colleagues,

We would like to compare the NONMEM predictions with those obtained by a Ba=
yesian TDM software for models describing the residual unexplained variabil=
ity with exponential errors.

We need to know if NONMEM performs a first order Taylor expansion of the ex=
ponential error when data are fitted by the FOCE method:
Y=F*EXP(EPS(1)) -> Y= F*(1+EPS(1)).

Could someone help with this?
Thanks in advance
Monia

Monia Guidi, PhD

Pharmacometrician
Service of Clinical Pharmacology | University Hospital and University of La=
usanne
Center of research and innovation in Clinical Pharmaceutical Sciences | Uni=
versity Hospital and University of Lausanne
BU17 01/193
CH-1011 Lausanne
email: monia.guidi
tel: +41 21 314 38 97


CHUV
centre hospitalier universitaire vaudois

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Received on Mon Jul 19 2021 - 11:34:06 EDT

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