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Postdoctoral Research Positions in the Savic lab of the University of California, San Francisco (UCSF)

From: Shaffer, Craig H <Craig.Shaffer>
Date: Sun, 15 Aug 2021 18:05:24 +0000

Postdoctoral Research in the Savic Integrative Pharmacology Laboratory.

Background: The research laboratory of Dr. Rada Savic in the Department of =
Bioengineering and Therapeutic Sciences of the University of California, Sa=
n Francisco (UCSF) is engaged in groundbreaking drug development projects f=
or infectious diseases including tuberculosis, HIV, malaria, and COVID-19 a=
s well as pain management and autoimmune disease with a focus on identifyin=
g optimal treatment regimens. We develop and apply disease models, perform =
pharmacokinetic and pharmacodynamic evaluations, build physiology-based pha=
rmacokinetic models, conduct exposure-response analyses, and utilize model-=
based simulations with the ultimate goal to optimize treatment in adult and=
 pediatric patient populations. While pharmacokinetic-pharmacodynamic conce=
pts and advanced quantitative clinical pharmacology principles have been in=
tegrated into the clinical development of compounds across many therapeutic=
 areas, human dose prediction and early clinical evaluation of the efficacy=
 and safety of candidate molecules for infectious diseases remains empirica=
l. Innovative approaches are required to enable effective translation of no=
nclinical data, providing insight into the selection of rational treatment =
combinations and optimized clinical trial designs.

The Savic Lab is seeking experienced researchers and scholars of exceptiona=
l promise for postdoctoral fellow positions in interdisciplinary research w=
ith expertise in the methods and theory of statistics, data science, applie=
d mathematics and pharmacometrics or related fields (e.g., pharmacokinetics=
, pharmacodynamics, quantitative pharmacology, systemic pharmacology, compu=
tational biology). As a part of the Savic lab, you will develop innovative=
 models that integrate new data and/or new experiments, implement new mathe=
matical and statistical techniques and approaches, and contribute to establ=
ishing pharmacometric capabilities and infrastructure (e.g., lead the devel=
opment of tools for recurrent and consistent analysis, develop guidance doc=
uments and standards of practice). In addition to these roles, the postdoct=
oral fellow will have opportunities to teach and supervise graduate student=
s, write scientific papers, present research findings at international conf=
erences, and write and submit grant applications.

Pharmacometrics is an emerging discipline that uses mathematical and statis=
tical tools to quantify drug, disease, and trial information to aid efficie=
nt drug development and regulatory decisions. It designs and applies mathem=
atical models to describe the relationship between drug exposure (pharmacok=
inetics) and response (pharmacodynamics) for both desired and undesired eff=
ects and aims to include in such models, the effects of individual patient =
characteristics with the ultimate goal to give the right drug at the right =
dose to the right patient at the right time. Dr. Savicís Pharmacometrics =
Team has established translational and clinical drug development expertise =
across many disease areas and is active internationally enjoying impactful =
collaborations and exchange programs with the most renowned clinical trial =
networks and modelling groups worldwide.

Required skills: In addition to enthusiasm, motivation and independent thin=
king, candidates must have a working knowledge of pharmacokinetic-pharmacod=
ynamic modelling and simulation, including some advanced statistical princi=
ples (nonlinear mixed effects modelling, Bayesian statistics, clinical tria=
l simulations). Strong programming skills in R, Metlab or Python and experi=
ence in NONMEM are essential. Knowledge of drug development, high-performan=
ce computing, and dynamic modeling are preferred.

Ideal candidates will have a passion about scientific research with the wil=
lingness and ability to learn and integrate knowledge from across different=
 therapeutic areas. Personal skills such as teamwork, accurate listening, s=
trategic thinking, along with very good oral and written English language s=
kills will be critical for the successful candidates.

Post-doctoral research fellow candidates should have completed or obtained =
a PhD in a relevant discipline such as statistics, data science, applied ma=
thematics, pharmacometrics or related fields (eg pharmacokinetics, pharmaco=
dynamics, quantitative pharmacology, systemic pharmacology, computational b=
iology), and have published their research in a peer reviewed journal.

The successful candidates will be co-located with the modeling team in Savi=
c Laboratory on the Mission Bay campus of UCSF.

Salary is commensurate with experience. E-mail a curriculum vitae, a letter=
 stating research interests and contact information for three references to=
: rada.savic

Deadline for applications: 18 November 2021.

UC San Francisco seeks candidates whose experience, teaching, research, or =
community service that has prepared them to contribute to our commitment to=
 diversity and excellence. The University of California is an Equal Opportu=
nity/Affirmative Action Employer. All qualified applicants will receive con=
sideration for employment without regard to race, color, religion, sex, sex=
ual orientation, gender identity, national origin, disability, age or prote=
cted veteran status.

Best regards,

Craig Shaffer

Director, Strategy and Operations

Savic Integrative Pharmacology Research Laboratory

Department of Bioengineering & Therapeutic Sciences<>

Schools of Pharmacy and Medicine

University of California, San Francisco

E-mail: craig.shaffer

Received on Sun Aug 15 2021 - 14:05:24 EDT

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