NONMEM Users Network Archive

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Re: Manchester PBPK

From: Hitesh Mistry <hitesh.mistry>
Date: Tue, 3 Aug 2021 22:06:07 +0000

P.S.

Its online too: https://manchester.shinyapps.io/pbpk/ It can handle 50 conc=
urrent users and will timeout after 1 hour of inactivity.


________________________________
From: Hitesh Mistry
Sent: Monday, August 2, 2021 2:53 PM
To: nmusers
Subject: Manchester PBPK

Hello NONMEM users,

We (Nicola Melillo and Hitesh Mistry) would like to introduce a Shiny PBPK =
app entitled, "Manchester PBPK", which can be used for exploring mean botto=
m up PK simulations in different species. The code is kept simple and it is=
 open-source (https://github.com/NicolaMelillo/ManchesterPBPK), so that one=
 can easily view all the equations and how they link together to generate c=
oncentration time-profiles in different organs. It can be used for teaching=
 but also to simply explore a new compound for which only in-vitro data is =
available.

The code/model will be further developed based on feedback we receive over =
time. If others want to edit/develop aspects please feel free to do so.

Enjoy,
Hitesh Mistry (Division of Pharmacy, Division of Cancer Sciences, Universit=
y of Manchester)
Nicola Melillo (ex-Division of Pharmacy, University of Manchester)

Received on Tue Aug 03 2021 - 18:06:07 EDT

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