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Principal Scientist/Associate Director level DMPK Modeling and Simulations Role

From: TJ Elder <telder>
Date: Tue, 1 Sep 2020 13:28:56 +0000

Our Client in the Boston area is looking for a strong PhD level scientist t=
o deliver mechanistic and quantitative PK/PD/efficacy relationships to supp=
ort project teams from early discovery through early clinical development.

In addition, the individual will be involved in (PK) and (ADME) studies of =
to support drug development from early discovery through preclinical and cl=
inical development. The individual will serve as DMPK project representativ=
e to coordinate and lead all nonclinical DMPK activities on programs from r=
esearch phase through development. An individual with in-depth knowledge an=
d expertise in PK/PD modeling and simulation and ADME is essential.

Responsibilities:
Provide quantitative and mechanistic PK/PD/efficacy relationships to suppor=
t drug discovery and development teams
Design/execute preclinical studies to understand the (PK) and (ADME) of dru=
g candidates
Represent DMPK as the subject matter expert on project teams, develop and d=
rive DMPK and PK/PD strategy for Drug Discovery projects
Participate and manage CROs in the conduct of in vitro/in vivo ADME studies
Qualifications
PhD. with years of experience in the biopharmaceutical industry, with evide=
nce of modeling experience
Fluency with simulations and modeling, and in depth hands-on modeling exper=
ience (e.g. using WinNonlin Phoenix, MATLAB/Simbiology, PK Sim, Simcyp, or =
NONMEM to develop PK/PD models)
Solid knowledge of metabolism, ADM, PK/PD and bioanalytical principles is r=
equired.
Experience with biologics desirable but not required.
Strong communication and presentation skills required
Excellent interpersonal skills



For more information please contact:

TJ Elder
Search Consultant
Pre-Clinical Development
O: 413.458.6124
C: 413.207.7676
https://www.linkedin.com/in/tjelder/
telder


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Received on Tue Sep 01 2020 - 09:28:56 EDT

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