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Webinar: Do you need a life scientist for QSP modeling?

From: Rebecca Baillie <rbaillie>
Date: Mon, 12 Oct 2020 18:30:59 +0000

Do you need a life scientist for QSP modeling?
Katherine Kudrycki, PhD, Principal Scientist at Rosa & Co. LLC
On October 14, 2020 at 12:00-1:00 PM EST
Register for free at https://www.rosaandco.com/webinars

Abstract:
While QSP models are defined as comprehensive models of biological mechanis=
ms, the inclusion and role of life scientists and disease area experts in m=
odel development are often omitted or overlooked. This webinar addresses ho=
w including dedicated life scientists on the QSP modeling team can improve =
model quality and enhance research results.
QSP modeling begins with scoping of the biological system and progresses to=
 include equations and parameters consistent with physical and biochemical =
principles. Each decision in the development and qualification of QSP model=
s requires scientific judgment. Life scientists with expertise and experien=
ce in the appropriate therapeutic area or biological field can provide esse=
ntial input for the design of the model. Life scientists apply expert judgm=
ent to make scope decisions, assess data, inform assumptions where knowledg=
e gaps exist and provide a biologically relevant interpretation of model si=
mulation results. Without dedicated expert life scientist input, a team may=
 run the risk of building models that "work" but are not fit for purpose or=
 are not biologically sound. For example, a model may show good agreement w=
ith data on previously measured outcomes but have unrealistic parameter val=
ues or qualitative behaviors that are clear to a biologist.
Life scientists' interpretation of simulation results can improve the likel=
ihood of meaningful and actionable conclusions. The life scientists can als=
o help the team to communicate these results in a way relevant to the proje=
ct's stakeholders. Having dedicated life scientists on the team leads to mo=
re efficient model building, qualification, and interpretation of the resul=
ts, and can help ensure impact.


Received on Mon Oct 12 2020 - 14:30:59 EDT

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