From: Bach, Thanh H Y <*thanh-bach*>

Date: Thu, 8 Oct 2020 20:24:30 +0000

Hi all,

I am running a model using IMP method. Model optimization was successful but no covarance matrix was output unless I specify UNCONDITIONAL in the $COV block. Any idea why?

When I read the user guide, it said that UNCONDITIONAL is needed if we want the covariance step to be implemented even when model minimization fails. It did not mention anything about successful minimization but no covariance output. I also checked NONMEM output file for my model and there was not error message either, so I am not sure the missing covariance matrix was due to $COV failure or any other reason.

Following is a snapshot of my model output

iteration 90 OBJ= 6617.1481876524931 eff.= 93. Smpl.= 300. Fit.= 0.88856

#TERM:

OPTIMIZATION WAS COMPLETED

ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,

AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.

ETABAR: 4.9637E-03 9.3967E-03 3.7603E-05 -1.9003E-04

SE: 4.9923E-02 9.6445E-02 2.7522E-02 2.6685E-03

N: 56 56 56 56

P VAL.: 9.2080E-01 9.2238E-01 9.9891E-01 9.4323E-01

ETASHRINKSD(%) 2.7783E+00 1.7267E+01 5.3092E+00 6.9977E+01

ETASHRINKVR(%) 5.4794E+00 3.1553E+01 1.0337E+01 9.0986E+01

EBVSHRINKSD(%) 2.7482E+00 1.7184E+01 5.6691E+00 7.0131E+01

EBVSHRINKVR(%) 5.4209E+00 3.1415E+01 1.1017E+01 9.1078E+01

EPSSHRINKSD(%) 1.2374E+01 1.2374E+01

EPSSHRINKVR(%) 2.3217E+01 2.3217E+01

TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 578

N*LOG(2PI) CONSTANT TO OBJECTIVE FUNCTION: 1062.2929443846017

OBJECTIVE FUNCTION VALUE WITHOUT CONSTANT: 6617.1481876524931

OBJECTIVE FUNCTION VALUE WITH CONSTANT: 7679.4411320370946

REPORTED OBJECTIVE FUNCTION DOES NOT CONTAIN CONSTANT

TOTAL EFFECTIVE ETAS (NIND*NETA): 224

#TERE:

Elapsed estimation time in seconds: 28.83

Number of Negative Eigenvalues in Matrix= 1

Most negative value= -7.5944835791791885

Most positive value= 29811.764851258835

Forcing positive definiteness

Root mean square deviation of matrix from original= 6.6243382481674822E-006

Elapsed covariance time in seconds: 0.28

Thank you in advance for your feedback

Received on Thu Oct 08 2020 - 16:24:30 EDT

Date: Thu, 8 Oct 2020 20:24:30 +0000

Hi all,

I am running a model using IMP method. Model optimization was successful but no covarance matrix was output unless I specify UNCONDITIONAL in the $COV block. Any idea why?

When I read the user guide, it said that UNCONDITIONAL is needed if we want the covariance step to be implemented even when model minimization fails. It did not mention anything about successful minimization but no covariance output. I also checked NONMEM output file for my model and there was not error message either, so I am not sure the missing covariance matrix was due to $COV failure or any other reason.

Following is a snapshot of my model output

iteration 90 OBJ= 6617.1481876524931 eff.= 93. Smpl.= 300. Fit.= 0.88856

#TERM:

OPTIMIZATION WAS COMPLETED

ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,

AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.

ETABAR: 4.9637E-03 9.3967E-03 3.7603E-05 -1.9003E-04

SE: 4.9923E-02 9.6445E-02 2.7522E-02 2.6685E-03

N: 56 56 56 56

P VAL.: 9.2080E-01 9.2238E-01 9.9891E-01 9.4323E-01

ETASHRINKSD(%) 2.7783E+00 1.7267E+01 5.3092E+00 6.9977E+01

ETASHRINKVR(%) 5.4794E+00 3.1553E+01 1.0337E+01 9.0986E+01

EBVSHRINKSD(%) 2.7482E+00 1.7184E+01 5.6691E+00 7.0131E+01

EBVSHRINKVR(%) 5.4209E+00 3.1415E+01 1.1017E+01 9.1078E+01

EPSSHRINKSD(%) 1.2374E+01 1.2374E+01

EPSSHRINKVR(%) 2.3217E+01 2.3217E+01

TOTAL DATA POINTS NORMALLY DISTRIBUTED (N): 578

N*LOG(2PI) CONSTANT TO OBJECTIVE FUNCTION: 1062.2929443846017

OBJECTIVE FUNCTION VALUE WITHOUT CONSTANT: 6617.1481876524931

OBJECTIVE FUNCTION VALUE WITH CONSTANT: 7679.4411320370946

REPORTED OBJECTIVE FUNCTION DOES NOT CONTAIN CONSTANT

TOTAL EFFECTIVE ETAS (NIND*NETA): 224

#TERE:

Elapsed estimation time in seconds: 28.83

Number of Negative Eigenvalues in Matrix= 1

Most negative value= -7.5944835791791885

Most positive value= 29811.764851258835

Forcing positive definiteness

Root mean square deviation of matrix from original= 6.6243382481674822E-006

Elapsed covariance time in seconds: 0.28

Thank you in advance for your feedback

Received on Thu Oct 08 2020 - 16:24:30 EDT