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Upcoming webinar: Using QSP to predict cardiotoxicity caused by cancer drugs

From: Rebecca Baillie <rbaillie>
Date: Mon, 16 Nov 2020 16:54:42 +0000

Using QSP to predict cardiotoxicity caused by cancer drugs
Eric Sobie, PhD
Professor, Pharmacological Sciences at Icahn School of Medicine at Mount Si=
nai

November 18, 2020 at 12:00-1:00 PM EST

Register for free at https://www.rosaandco.com/webinars

Abstract
Tyrosine kinase inhibitor drugs, or TKIs, have been highly effective at tre=
ating several types of cancer, yet many TKIs are associated with various fo=
rms of cardiotoxicity. The mechanisms underlying these drug-induced adverse=
 events remain poorly understood.
We are exploring potential mechanisms of TKI-induced cardiotoxicity using a=
 strategy that integrates several complementary approaches. The pipeline in=
volves: (1) transcriptomics to quantify drug-induced changes in gene expres=
sion in stem cell-derived myocytes (iPSC-CMs); (2) mechanistic QSP modeling=
 to predict subsequent changes in physiological dynamics; and (3) physiolog=
ical measurements to confirm or refute model predictions. This QSP approach=
 successfully predicted individual-specific TKI susceptibility whereby part=
icular drugs were tolerated in one cell line but disrupted dynamics in anot=
her cell line.
Overall, the work offers new insight into cardiotoxicity caused by TKIs and=
 illustrates a novel approach for integrating transcriptomic measurements a=
nd QSP models to generate experimentally testable, individual-specific pred=
ictions.




Received on Mon Nov 16 2020 - 11:54:42 EST

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