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Re: SEED status with SAEM method

From: Jeroen Elassaiss-Schaap <jeroen>
Date: Thu, 5 Nov 2020 10:21:42 +0100

Dear Le Ba,

The most optimal way would be to tune other SAEM settings to see whether
the results become more insensitive to the seed. Your use of a lower
NBURN might be because you do not reach convergence. If that is indeed
the case, that would also an objective to reach by improving settings.
There are many settings to tune, please refer to the nonmem guide
(nm7XX.pdf) for a list of options.

Hope this helps,

Jeroen

http://pd-value.com
jeroen
  
+31 6 23118438
-- More value out of your data!

On 5/11/20 9:41 am, hai le ba wrote:
> Hello nmusers,
> I've tried to test the SAEM method on my dataset (1 sample for each
> ID) with different SEED status. Sometimes, I've got good results (with
> RSE <50%), but sometimes I can't get it.
> Example:
> $EST METHOD=SAEM INTERACTION NBURN=3000 NITER=500 AUTO=1 PRINT=100
> SEED=123456789
> $EST METHOD=IMP EONLY=1 PRINT=1 NITER=5 ISAMPLE=1000 MAPITER=0
> I've got EPS : 0.00064 (RSE=63%)
>
> but
> $EST METHOD=SAEM INTERACTION NBURN=3000 NITER=500 AUTO=1 PRINT=100
> SEED=123235489
> $EST METHOD=IMP EONLY=1 PRINT=1 NITER=5 ISAMPLE=1000 MAPITER=0
> I've got EPS : 0.0223 (RSE=18%)
>
> Could i trust on the good results (EPS=0.0223)? How can we control
> this problem?
>
> Thank you very much,
> Hai, LE Ba
> Ph.D Student
> La faculté de Pharmacie - Aix Marseille université
> Hanoi university of Pharmacy
> Email: lebahai01
> hailb
> bahai.le

Received on Thu Nov 05 2020 - 04:21:42 EST

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