NONMEM Users Network Archive

Hosted by Cognigen

Webinar on Modeling and Policy Change

From: Rebecca Baillie <rbaillie>
Date: Mon, 11 May 2020 18:07:47 +0000

Of "clever" models and "dumb" spreadsheets": what is more effective to driv=
e policy change?
Paolo Denti, PhD, Associate Professor at the University of Cape Town
When: Wednesday May 20, 2020, 12:00 to 1:00 pm EDT
Register for free at
What often prevents modelling results from contributing to policy change is=
 not lack of good science, but ineffective communication to the target audi=
ence of clinicians and decision-makers.
Dosing of anti-infectives in children is a glaring example of this. While t=
he theory of maturation and allometric scaling are widely assumed as the go=
ld standard within the pharmacokinetic modelling community, a number of int=
ernational guidelines for dosing in children is still based on weight-bands=
 targeting the same mg/kg dose as in adults. This happens for drugs in negl=
ected diseases, when no directly observed data is available in children, bu=
t also for common diseases such as HIV or tuberculosis. This results in mil=
lions of children potentially receiving sub-optimal doses.
How can we get across the message of our models and use it to improve polic=
y? Sometimes a simple and easy-to-use solution like an Excel spreadsheet ca=
n do the trick better than sleek-looking Visual Predictive Checks and impre=
ssively low parameter precision or shrinkage values.

Received on Mon May 11 2020 - 14:07:47 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: