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Genmab Netherlands opportunity for Scientist Quantitative Pharmacology

From: Sieto Bosgra <SIB>
Date: Tue, 15 Dec 2020 12:16:41 +0000

Dear colleagues,

We have an interesting position available for a Scientist Quantitative Phar=
macology at Genmab's global R&D center in Utrecht, the Netherlands. The jo=
b details are below. Follow one of these links to apply:
Scientist Quantitative Pharmacology | Genmab | LinkedIn<https://www.linkedi=
n.com/jobs/view/2330412867/?refId=sGFe4qc6jLtRnZvnuiQlVQ%3D%3D&trackingId=
=8vT52pj5%2FIM2ppW1mYs33w%3D%3D>
Scientist Quantitative Pharmacology (myworkdayjobs.com)<https://genmab.wd3.=
myworkdayjobs.com/en-US/Genmab_Careers_Site/job/Utrecht/Scientist-Quantitat=
ive-Pharmacology_R866>

Our team will also be expanding in Princeton (NJ) with openings in Clinical=
 and Quantitative Pharmacology and QSP modeling. Check www.genmab.com or Li=
nkedIn for more information.

####

Genmab is focused on the creation and development of innovative and differe=
ntiated antibody products, with the aim of improving the lives of cancer pa=
tients.

Role
The Quantitative Pharmacology Scientist will provide pharmacology expertise=
 to programs through all stages of research and development. The person wil=
l contribute to the design of non-clinical studies and will be responsible =
for interpretation and reporting of pharmacokinetics, toxicokinetics and ph=
armacodynamics of drug candidates. This individual will help generate an in=
-depth understanding of all aspects of PK and PD of Genmab's next generatio=
n antibody technologies by building and refining platform quantitative syst=
em pharmacology models, and applying these models to guide rational experim=
ental designs and critical decisions on candidate antibody therapies.
In this role they will also work on the execution of pre-clinical and clini=
cal development programs in close collaboration with scientists in Translat=
ional Research and Clinical Development, conducting quantitative PK/PD/safe=
ty/efficacy analyses for integration into overall program strategies. They =
will provide rationale for dose regimen selection in first in human (FIH) t=
rials and beyond, and identification of circumstances where dose adjustment=
 or patient selection/stratification should be considered.
This is an exciting opportunity to be part of a passionate, high profile, h=
igh-impact Pharmacology team, and to work in a highly dynamic and collabora=
tive setting, with opportunities for professional development.

Responsibilities
* Provides pharmacology support to multi-disciplinary study teams f=
or pre-clinical and clinical programs.
* Contributes expert pharmacology input into key pre-clinical, clin=
ical, and regulatory documents including study protocols, study reports, in=
vestigator brochures, and other documents within agreed timelines.
* Assumes responsibility for TK, PK and PD evaluation and reporting=
 in assigned non-clinical studies.
* Contributes to building and refining platform quantitative system=
 pharmacology models to generate in-depth understanding of PK/PD characteri=
stics of proprietary antibody technologies.
* Helps define and execute PK/PD modeling and simulation plans to g=
uide rational first in human dose projection and dose selection.
* Leads clinical pharmacology efforts (e.g., study design, protocol=
 concepts/protocols preparation, clinical phase oversight, data analysis, a=
nd reporting) within assigned programs to yield high value PK/PD insight fo=
r critical decisions.
* Analyzes results, interprets, and recommends action based on stud=
y results.
* Performs PK and PK/PD analyses using a variety of tools and appro=
aches.
* Integrates, interprets, and reports data to project teams and oth=
er customers.
* Serves on Global Pre-Clinical and Clinical Development Teams and =
provides a source of Pharmacology expertise and advice to other functions a=
cross Genmab.
* Performs other responsibilities as requested by management.

Requirements
* A PharmD or PhD in Clinical Pharmacology, Pharmacology, Pharmacok=
inetics, or related discipline is required.
* Approximately 0-2 years of experience in pre-clinical and/or clin=
ical pharmacology in pharma, biotechnology, or consulting.
* Experience with noncompartmental PK analysis, allometric scaling,=
 analysis of pre-clinical and/or clinical PK/PD data is also required.
* Affinity for quantitative methods and demonstrated ability to app=
ly modeling and simulation approaches to pre-clinical and clinical drug dev=
elopment are required.
* Hands-on experience with programming in R is highly desired.
* Experience with application of quantitative tools such as WinNonL=
in/Phoenix, NONMEM, and/or other PK/PD analysis software is preferred.
* An understanding of antibody therapeutics development and experie=
nce in the field of oncology or immunology are considered beneficial.
* Flexible, with a positive and proactive attitude, ability to work=
 with multidisciplinary teams, prioritize projects effectively and communic=
ate at all levels within the company.
* Excellent written, verbal, and interpersonal communication skills=
.

In case you have any questions, please feel free to reach out to Recruiter =
Mark Stickland at ext-fts-mst
Genmab employees work with determination and with respect for each other, c=
onsistent with our core values, to achieve our common goals. We give indivi=
duals and teams the autonomy to drive development of innovative products an=
d solutions, knowing that integrity is a core value throughout our company.=
 Genmab will offer the successful application a challenging position, where=
 the right candidate will have the opportunity to work with highly speciali=
sed people across functions in an informal, multicultural culture, all aimi=
ng to make a difference for cancer patients.

Teamwork and respect are central pillars of Genmab's culture and we therefo=
re ensure an inclusive, open, and supportive professional work environment =
across our international locations. We believe that fostering workplace div=
ersity across social, educational, cultural, national, age and gender lines=
 is a prerequisite for the continued success of the company. We are committ=
ed to diversity at all levels of the company and strive to recruit employee=
s with the right skills and competences, regardless of gender, age, ethnici=
ty, etc.

Please note that if you are applying for a position in the Netherlands; Gen=
mab's policy for all permanently budgeted hires in this location is to offe=
r a temporary agreement for one year, followed by a contract for indefinite=
 time regardless of seniority.
Genmab A/S is committed to protecting your personal data and privacy. Pleas=
e see our privacy policy for handling your data in connection with you appl=
ication on our website https://www.genmab.com/privacy.
* Apply


Received on Tue Dec 15 2020 - 07:16:41 EST

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