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Variability in Dosing Rate (and amount)

From: Paul Hutson <paul.hutson>
Date: Thu, 10 Dec 2020 04:23:00 +0000

Dear Users, I hope that someone can suggest a paper or method for addressin=
g an issue with which I am grappling.
I am working on a mouse toxicokinetic study that has two basic cohorts. On=
e received a bolus gavage dose of known dose and time. The other was dosed=
 by drug-laden chose. The chow and thus drug ingested was measured, usuall=
y daily in the morning, but sometimes after 2-3 days. The "daily dose" of =
chow was averaged over the 12 hours of the daily dark period in which the a=
nimals were considered to be eating their chow. 2-3 blood samples were obt=
ained from each animal, and the basic 2 compartmental SEAM IMP method is co=
nverging well on the gavage-only data.
Can the group suggest how to address the uncertainty in the rate of dosing =
over the 12 hour dark period? Of additional concern, hard to deal with, is=
 the potential that nightly chose ingestion varied over a series of 1-3 day=
s. I don't think that the 12 August 2020 thread on a random effect on ALAG=
 applies to this case.
Many thanks.

Paul Hutson, PharmD, BCOP
UWisc School of Pharmacy
T: 608.263.2496
F: 608.265.5421

Received on Wed Dec 09 2020 - 23:23:00 EST

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