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Webinar: gQSPSim: a SimBiology-based GUI app for standardized QSP model development and application

From: Rebecca Baillie <rbaillie>
Date: Wed, 8 Apr 2020 19:28:30 +0000

gQSPSim: a SimBiology-based GUI app for standardized QSP model development =
and application

Iraj Hosseini, PhD and Justin Feigelman, PhD
 Scientists at Genentech, Inc

Wednesday, April 15, 2020, 12:00 to 1:00 pm EDT

Register for free at https://register.gotowebinar.com/register/587288123574=
4396299?source=website

Abstract:
Quantitative Systems Pharmacology (QSP) models are often implemented using =
a wide variety of technical workflows and methodologies. To facilitate repr=
oducibility, transparency, portability, and reuse for QSP models, we have d=
eveloped gQSPSim, a GUI-based MATLAB(r) application that performs key steps=
 in QSP model development and analyses.

The capabilities of gQSPSim include 1) model calibration using global and l=
ocal optimization methods, 2) development of virtual subjects to explore va=
riability and uncertainty in the represented biology, and 3) simulations of=
 virtual populations for different interventions. gQSPSim works with SimBio=
logy(r)-built models, utilizing components such as species, doses, variants=
, and rules. All functionalities are equipped with an interactive visualiza=
tion interface and the ability to generate presentation-ready figures. In a=
ddition, standardized gQSPSim sessions can be shared or saved for future ex=
tension and reuse.

In this work, we demonstrate gQSPSim's capabilities with a standard target-=
mediated drug disposition model and a published model of anti-PCSK9 treatme=
nt of hypercholesterolemia.




Received on Wed Apr 08 2020 - 15:28:30 EDT

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