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[NMusers] Clinical Pharmacology Modelling & Simulation Role at GlaxoSmithKline

From: Chao Chen <chao.c.chen_at_gsk.com>
Date: Wed, 30 Oct 2019 11:14:47 +0000

A new position has come up in our Clinical Pharmacology Modelling and Simul=
ation Group (CPMS) at our Greater London site. This is an excellent role to=
 use quantitative clinical pharmacology to accelerate the delivery of new m=
edicines to patients, by enhancing drug development efficiency and business=
 decision quality. The work directly supports our mission to help our patie=
nts do more, feel better and live longer.
The clinical PK/PD modeler will provide technical, therapeutic, and product=
 development support for GlaxoSmithKline projects across all therapeutic ar=
eas. Individuals will ensure the optimal application of Clinical Pharmacoki=
netic (PK), Pharmacodynamic (PD), and Modelling & Simulation (MS) principle=
s towards efficient drug development, risk management, and product registra=
tion. Responsibilities generally commence at pre-clinical candidate selecti=
on and continue through product lifecycle management.
Principle accountabilities include both modelling/simulation activities and=
 clinical pharmacology support:
* Plan, execute and report translational drug-disease modelling, expo=
sure-response analysis, simulation-based trial design and population clinic=
al pharmacology
* Contribute to clinical program design, trial protocols, analysis pl=
ans, study reports and regulatory submissions
* Apply innovative methods such as longitudinal exposure-response ana=
lysis, model-based meta-analysis and item-response analysis to improve data=
 use and trial efficiency
* Present strategy and defend outcome of model-based approaches to in=
ternal governance boards and regulatory agencies
* Promote model-informed drug discovery and development through exter=
nal collaboration, journal publication and conference presentation

Basic Qualifications/Competencies:
* A doctorate relevant to Quantitative Clinical Pharmacology, and exp=
erience in using modelling/simulation to solve practical problems in indust=
ry or academia
* Proven skills in PK/PD and longitudinal disease modelling; and veri=
fiable proficiency in pharmacometric tools NONMEM, Monolix, R or SAS
* Strong drive and learning agility to build knowledge on a drug-dise=
ase system, symptom progression, standard of care, and trial design and end=
points
* Demonstrated aptitude for productive collaboration in a multi-disci=
pline team, with effective communication and taking personal accountability=
 for timely delivery of results
* Clear evidence of ability to make sound judgement in complex situat=
ions and adapt to changing business needs by prioritising multiple tasks

Preferred Qualifications:
* Experience in the design, analysis, interpretation and reporting of=
 Clinical PK and PK/PD studies.
* Experience or demonstrated aptitude in the application of clinical =
PK and PK/PD to the drug development process.
* Knowledge of pharmacology, biology, drug metabolism, biopharmaceuti=
cs, regulatory affairs, therapeutics and commercialization such that he/she=
 can assist in managing these interfaces and ensure that CPMS input meets t=
heir needs.

Why GSK?
Our values and expectations are at the heart of everything we do and form a=
n important part of our culture. These include Patient focus, Transparency,=
 Respect, Integrity along with Courage, Accountability, Development, and Te=
amwork. As GSK focuses on our values and expectations and a culture of inno=
vation, performance, and trust, the successful candidate will demonstrate t=
he following capabilities:

* Operating at pace and agile decision-making - using evidence and ap=
plying judgement to balance pace, rigour and risk.
* Committed to delivering high quality results, overcoming challenges=
, focusing on what matters, execution.
* Continuously looking for opportunities to learn, build skills and s=
hare learning.
* Sustaining energy and well-being
* Building strong relationships and collaboration, honest and open co=
nversations.
* Budgeting and cost-consciousness

At GSK, we develop therapies of various modalities for a broad range of ind=
ications. As a member of a global department with diverse expertise, you wi=
ll enjoy a highly supportive environment for scientific innovation, busines=
s impact and professional growth. This position is open for application til=
l Wednesday 5th August 2019. Interested persons are encouraged to apply onl=
ine here<https://jobs.gsk.com/en-gb/jobs/230574?lang=en-us&previousLocale=
=en-GB>.
Chao Chen
Clinical Pharmacology Modelling & Simulation
GlaxoSmithKline R&D

GSK monitors email communications sent to and from GSK in order to protect =
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member of the GlaxoSmithKline group of companies. The
registered address of GlaxoSmithKline Services Unlimited
is 980 Great West Road, Brentford, Middlesex TW8 9GS.


Received on Wed Oct 30 2019 - 07:14:47 EDT

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