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2 courses in NJ, March 9-13, 2020

From: Andrew Hooker <Andrew.Hooker>
Date: Wed, 27 Nov 2019 15:18:24 +0000

Dear all,

We are pleased to offer 2 courses “Advanced methods for population model building, evaluation and usage in NONMEM” and “Pharmacometric modeling of composite score outcomes” in Lambertville, New Jersey March 9-11 and March 12-13, 2020. For more information see below and at http://www.uppsala-pharmacometrics.com.

Advanced methods for population model building, evaluation and usage in NONMEM

Pharmacometric modeling has become a pillar in model informed drug development (MIDD). With this comes expectations with respect to quality, efficiency, transparency and innovation in the implementation of the modeling and decision-making process. In this course we will present methods that will help make model building of standard problems more efficient and improve the final product. Further, it will give modelers a larger toolset of diagnostics and model components when it comes to development of models for challenging situations. Automated procedures recently developed for PsN & R facilitates a comprehensive assessment of a model and tailored functionality allow command-line transformations of models.

On March 9-11 in Lambertville, NJ, Mats Karlsson and Andrew Hooker will give a 2.5-day course on “Advanced methods for population model building, evaluation and usage in NONMEM”. The course presents strategies for model building and improvement, the latest methods for model evaluation, as well as strategies to consider when utilizing models for model-informed drug development.

The course consists of both lectures and hands-on computer exercises applying the methods discussed. This hands-on material is based on the most recent developments from NONMEM 7.4, PsN and Xpose. Participants get a vast amount of hands-on examples, code, code snippets and lecture material that can be useful on a daily basis.

If you want to learn how to use tools and methods for fast, efficient and comprehensive model building, evaluation and usage, come join us in March!

Topics covered:

  * Model building and model components
     * Overall modeling strategies
     * Random effects models (standard and extended)
     * Residual error models (standard and extended)
     * Mixture modeling
     * Handling censored data (e.g. BQL and dropout)
     * Covariate models and model building
     * Estimation methods and settings
  * Model evaluation
     * Prediction- and Residual-based
     * Empirical Bayes Estimate (EBE) and sampling-based diagnostics
     * Simulation and Simulation-Evaluation/Estimation-Based
     * Outlier and influential individual diagnostics
     * Automated evaluations
     * Covariate model focused diagnostics
     * Parameter uncertainty (bootstrap, SIR, COV)
  * To consider when applying models for informed drug development
     * Bias assessment
     * Power and Type I error
     * Model averaging

For more information and registration, see http://www.uppsala-pharmacometrics.com/build_diagnose_use_NJ_2020.html

Pharmacometric modeling of composite score outcomes

The EDSS in multiple sclerosis, the ACR scale for rheumatoid arthritis, or the MDS-UPDRS in Parkinson’s disease; these composite scales are as diverse as the diseases they are designed to measure. Composite scores also arise through patient-reported outcomes (PROs) that aim at measuring symptom status, physical function, mental health, and other measures important to patients. The wide range of novel pharmacometric models and approaches developed during the past years are a testament to the growing importance of this data type. This course will cover recent innovations and provide participants with a rich set of tools for analyzing composite scores in a wide variety of therapeutic areas. The course will illustrate how one can leverage finely grained item-level information but also how summary score data are most efficiently utilized. Throughout the course, questions of both model building and model-use will be discussed and presented in an interactive format including hands-on exercises.

On March 12-13 in Lambertville, NJ, Mats Karlsson and Sebastian Ueckert will give a 2-day course on “Pharmacometric modeling of composite score outcomes”. The course covers data aspects, model building, evaluation and use for composite score outcomes.

Topics covered:

  * Modeling data with item-level resolution using item response theory
  * Modeling total score data either as continuous or discrete data under a variety of models
  * Models for responder analysis to handle, e.g., ACR20/50/70 and PASI70/90
  * Pharmacometric modeling of Patient Reported Outcomes (PROs).
  * Model-based optimization of clinical trials with composite score outcomes

Intended course participants:
The course is designed for those who have a good working knowledge of pharmacometric analysis with experience in performing NONMEM analyses and/or have attended a NONMEM basic workshop.

For more information and registration, see http://www.uppsala-pharmacometrics.com/composite_scores_NJ_2020.html



Best regards,
Andrew

Andrew Hooker, Ph.D.
Associate Professor of Pharmacometrics
Dept. of Pharmaceutical Biosciences
Uppsala University
Box 591, 751 24, Uppsala, Sweden
Phone: +46 18 471 4355
Mobile: +46 768 000 725
www.farmbio.uu.se/research/researchgroups/pharmacometrics/








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Received on Wed Nov 27 2019 - 10:18:24 EST

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