NONMEM Users Network Archive

Hosted by Cognigen

RE: cumulative AUC

From: Yuan, Dongfen <Dongfen.Yuan>
Date: Wed, 20 Nov 2019 15:00:29 +0000

Hi Ruben,

This may not be a good idea: 1) evid = 4 reset all compartments; 2) when evid = 4, CMT is meant for dosing compartment (in my understanding, never tried). Please see the nonmem CMT PCMT data item help page.


Best regards,
Dongfen Yuan
PK Scientist
Parexel International
2520 Meridian Parkway
Durham, NC 27713, USA
t +1 919 748 6054
dongfen.yuan n
This communication, including any attachments, is intended only for the person or entity to which it is addressed and may contain confidential information. Any review, retransmission, distribution or other use of this information by persons or entities other than the intended recipient is prohibited. If you received this in error, please destroy any copies, contact the sender and delete the information from any computer. Thank you.

From: owner-nmusers
Sent: Friday, November 8, 2019 1:52 PM
To: Sam Liao <sliao m>
Cc: NMusers <nmusers
Subject: Re: [NMusers] cumulative AUC

Hi Sam,

Can't you simply dose with evid=4 (reset) into your auc compartment (cmt=4)?

Op vr 8 nov. 2019 19:09 schreef Sam Liao <sliao xresearch.com<mailto:sliao

Dear nmusers,

I have a question how to reset cumulative AUC in a $DES model, where DADT(4) is set up as cumulative AUC of C1.

Because the study is a four way crossover study, the cumulative value of A(4) need to rest to zero before each subsequent treatments.

However, NONMEM do not allow setting A(4) to zero in the statement of control stream.

Is there any work around of this problem?

Best regards,

Sam Liao
On 11/7/2019 7:17 AM, Farrell, Colm wrote:
At ICON, it’s our people that set us apart.
As a global provider of drug development solutions, our work is serious business. But that doesn’t mean you can’t have fun while you do it. With our vision to be the partner of choice in drug development, we hire only the best and brightest in the industry. Are you one of them?
Due to the continuing demand to support our clients in drug development through the integration of modelling and simulation into clinical development programs, ICON is looking for an experienced pharmacometrician to join our global PKPDM&S team, with a key responsibility to develop and apply M&S strategies, study designs and analyses across all phases of drug development. With members of the PKPDM&S based in UK and USA, we’re flexible on the location.
The role

• Prepare PKPDM&S-based strategies to support clinical development programs;

• Design, conduct, interpret and prepare appropriate study and regulatory summaries of PKPDM&S activities;

• Build and sustain great relationships with clients;

• Prepare and present scientific publications;

• Serve as scientific reviewer and staff mentor to colleagues.
What you need

• PhD (or equivalent experience) in pharmacokinetics/PKPD with proven industry or academic post PhD experience;

• Excellent understanding of the integration of PKPDM&S into clinical drug development

• Demonstrated expertise in hands-on population-based modelling e.g. NONMEM, Monolix and related software (R, Xpose, PsN);

• Proven mentorship capabilities.
Why join us
ICON enjoys a strong reputation for quality and is focused on staff development. We make it our mission to attract the most diverse and creative minds into the business and we continually strive to provide opportunities for our people to excel, grow and build a phenomenal career. We understand that our greatest asset is the skills and talents of our people and they are truly what set us apart. Other than working with a great team of switched on and ambitious people, we also offer a very competitive benefits package. This varies from country to country so a dedicated recruiter will discuss this with you at interview stage. We care about our people as they are the key to our success. We provide an open and friendly work environment where we empower people and provide them with opportunities to develop their long term career. ICON is an equal opportunity employer - M/F/D/V and committed to providing a workplace free of any discrimination or harassment.
To find out more and apply for the role, please visit: https://icon.wd3.myworkdayjobs.com/broadbean_external/job/UK-London-Marlow/Senior-PK-Scientist-II_061382-1



ICON plc made the following annotations.
------------------------------------------------------------------------------
This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message.

Thank You,

ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835

--

Sam Liao
Received on Wed Nov 20 2019 - 10:00:29 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.