NONMEM Users Network Archive

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RE: cumulative AUC

From: Yuan, Dongfen <Dongfen.Yuan>
Date: Wed, 20 Nov 2019 15:00:29 +0000

Hi Ruben,

This may not be a good idea: 1) evid = 4 reset all compartments; 2) when evid = 4, CMT is meant for dosing compartment (in my understanding, never tried). Please see the nonmem CMT PCMT data item help page.

Best regards,
Dongfen Yuan
PK Scientist
Parexel International
2520 Meridian Parkway
Durham, NC 27713, USA
t +1 919 748 6054
dongfen.yuan n
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From: owner-nmusers
Sent: Friday, November 8, 2019 1:52 PM
To: Sam Liao <sliao m>
Cc: NMusers <nmusers
Subject: Re: [NMusers] cumulative AUC

Hi Sam,

Can't you simply dose with evid=4 (reset) into your auc compartment (cmt=4)?

Op vr 8 nov. 2019 19:09 schreef Sam Liao <sliao<mailto:sliao

Dear nmusers,

I have a question how to reset cumulative AUC in a $DES model, where DADT(4) is set up as cumulative AUC of C1.

Because the study is a four way crossover study, the cumulative value of A(4) need to rest to zero before each subsequent treatments.

However, NONMEM do not allow setting A(4) to zero in the statement of control stream.

Is there any work around of this problem?

Best regards,

Sam Liao
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Sam Liao
Received on Wed Nov 20 2019 - 10:00:29 EST

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