NONMEM Users Network Archive

Hosted by Cognigen

Re: cumulative AUC

From: Ruben Faelens <ruben.faelens>
Date: Fri, 8 Nov 2019 19:52:06 +0100

Hi Sam,

Can't you simply dose with evid=4 (reset) into your auc compartment

Op vr 8 nov. 2019 19:09 schreef Sam Liao <sliao

> Dear nmusers,
> I have a question how to reset cumulative AUC in a $DES model, where
> DADT(4) is set up as cumulative AUC of C1.
> Because the study is a four way crossover study, the cumulative value of
> A(4) need to rest to zero before each subsequent treatments.
> However, NONMEM do not allow setting A(4) to zero in the statement of
> control stream.
> Is there any work around of this problem?
> Best regards,
> Sam Liao
> On 11/7/2019 7:17 AM, Farrell, Colm wrote:
> At ICON, it鈥檚 our people that set us apart.
> As a global provider of drug development solutions, our work is serious
> business. But that doesn鈥檛 mean you can鈥檛 have fun while =
you do it. With
> our vision to be the partner of choice in drug development, we hire only
> the best and brightest in the industry. Are you one of them?
> Due to the continuing demand to support our clients in drug development
> through the integration of modelling and simulation into clinical
> development programs, ICON is looking for an experienced pharmacometricia=
> to join our global PKPDM&S team, with a key responsibility to develop and
> apply M&S strategies, study designs and analyses across all phases of dru=
> development. With members of the PKPDM&S based in UK and USA, we鈥=
> flexible on the location.
> *The role*
> 路 Prepare PKPDM&S-based strategies to support clinical
> development programs;
> 路 Design, conduct, interpret and prepare appropriate study a=
> regulatory summaries of PKPDM&S activities;
> 路 Build and sustain great relationships with clients;
> 路 Prepare and present scientific publications;
> 路 Serve as scientific reviewer and staff mentor to colleague=
> *What you need*
> 路 PhD (or equivalent experience) in pharmacokinetics/PKPD wi=
> proven industry or academic post PhD experience;
> 路 Excellent understanding of the integration of PKPDM&S into
> clinical drug development
> 路 Demonstrated expertise in hands-on population-based modell=
> e.g. NONMEM, Monolix and related software (R, Xpose, PsN);
> 路 Proven mentorship capabilities.
> *Why join us*
> ICON enjoys a strong reputation for quality and is focused on staff
> development. We make it our mission to attract the most diverse and
> creative minds into the business and we continually strive to provide
> opportunities for our people to excel, grow and build a phenomenal career=
> We understand that our greatest asset is the skills and talents of our
> people and they are truly what set us apart. Other than working with a
> great team of switched on and ambitious people, we also offer a very
> competitive benefits package. This varies from country to country so a
> dedicated recruiter will discuss this with you at interview stage. We car=
> about our people as they are the key to our success. We provide an open a=
> friendly work environment where we empower people and provide them with
> opportunities to develop their long term career. ICON is an equal
> opportunity employer - M/F/D/V and committed to providing a workplace fre=
> of any discrimination or harassment.
> To find out more and apply for the role, please visit:
> ICON plc made the following annotations.
> -------------------------------------------------------------------------=
> This e-mail transmission may contain confidential or legally privileged
> information that is intended only for the individual or entity named in t=
> e-mail address. If you are not the intended recipient, you are hereby
> notified that any disclosure, copying, distribution, or reliance upon the
> contents of this e-mail is strictly prohibited. If you have received this
> e-mail transmission in error, please reply to the sender, so that ICON pl=
> can arrange for proper delivery, and then please delete the message.
> Thank You,
> ICON plc
> South County Business Park
> Leopardstown
> Dublin 18
> Ireland
> Registered number: 145835
> --
> Sam Liao

Received on Fri Nov 08 2019 - 13:52:06 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: