NONMEM Users Network Archive

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Re: cumulative AUC

From: R.terHeine
Date: Fri, 8 Nov 2019 18:25:21 +0000

Hi Sam,

You can activate a flag from 0 to 1 from a certain timepoint (eg FLA1) and integrate the auc as follows



Op 8 nov. 2019 om 19:16 heeft Sam Liao <sliao

Dear nmusers,

I have a question how to reset cumulative AUC in a $DES model, where DADT(4) is set up as cumulative AUC of C1.

Because the study is a four way crossover study, the cumulative value of A(4) need to rest to zero before each subsequent treatments.

However, NONMEM do not allow setting A(4) to zero in the statement of control stream.

Is there any work around of this problem?

Best regards,

Sam Liao

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Received on Fri Nov 08 2019 - 13:25:21 EST

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