NONMEM Users Network Archive

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Re: Using evid 0 before dosing

From: Carlos ST <carlos.serra91>
Date: Wed, 6 Nov 2019 15:48:09 +0000

Hi NMUsers community for you excellent suggestions. I will work through it.
Thanks,

Carlos



On Wed, 6 Nov 2019 at 15:12, Bill Denney <wdenney
>
> Hi Carlos,
>
> It is commonly used. For most datasets, there will be at least one
> observation that occurs before dosing to estimate the baseline value, and in
> almost every scenario, the modeling dataset should mirror the real world
> actions. So, there is no issue with it, and usually you will have an EVID=0
> before the first dose.
>
> Thanks,
>
> Bill
>
> -----Original Message-----
> From: owner-nmusers
> Of Carlos ST
> Sent: Wednesday, November 6, 2019 10:03 AM
> To: nmusers
> Subject: [NMusers] Using evid 0 before dosing
>
> Dear NMUsers,
>
> I would like advice in the best practice to use evid 0 before dosing, which
> is to say an observation just before a dosing (*to estimate the value in
> that compartment just before dosing event).
>
> Thank you,
>
> Carlos,
Received on Wed Nov 06 2019 - 10:48:09 EST

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