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Re: Log Transformed AST

From: Ranita Kirubakaran <r.kirubakaran>
Date: Tue, 23 Jul 2019 00:09:18 +0000

Dear all,

Thank you very much for the prompt reply - much appreciated.

Best Regards
Ranita K

From: William Denney <wdenney
Sent: Tuesday, July 23, 2019 10:04 AM
To: Duy Tran <duytran16
Cc: Ranita Kirubakaran <r.kirubakaran
Subject: Re: [NMusers] Log Transformed AST

Hi Ranita,

Duy is correct. NONMEM is based on FORTRAN, so usually the mathematical fu=
nctions and operators are borrowed from FORTRAN:



On Jul 22, 2019, at 19:49, Duy Tran <duytran16>> wrote:

If you desire to log transform by base 10 instead of e, use LOG10 in NONMEM=
 instead of LOG

On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran <r.kirubakaran
Dear all,

I am a PhD student working on NONMEM as a new user. I am working on externa=
l evaluation of some of the selected published population PK models. While =
trying to implement one of the models in NONMEM, I realised that if I code =
log-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the=
 sdtab output is giving me the In(AST) value instead of a LOG(AST) value. =
Was wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log =
10 (x)?

Thank you.

Best Regards,

Ranita Kirubakaran

PhD Candidate

Ranita Kirubakaran

PhD Candidate
St Vincentís Clinical School | UNSW Sydney
Department of Clinical Pharmacology and Toxicology
Therapeutics Centre | Level 2 Xavier Building
St Vincentís Hospital
390 Victoria Street | Darlinghurst NSW 2010 | Australia

E r.kirubakaran
u> | P +61 (2) 8382 2199 | F +61 (2) 8382 2724

Received on Mon Jul 22 2019 - 20:09:18 EDT

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