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[NMusers] Easier IOV modeling

From: Sebastien Bihorel <sebastien.bihorel_at_cognigencorp.com>
Date: Tue, 15 Jan 2019 22:06:45 -0500 (EST)

Hi

The Introduction to NONMEM 7.x documents include a section entitled "Easier Inter-occasion variability modeling" which describes a quicker way to code IOV.

$ABBR REPLACE ETA(OCC_CL)=ETA(4,7,10)
;when OCC=1, eta(4) to be used: when OCC=2, eta(7) to be used, etc.

...

$PK
CL=TVCL*EXP(ETA(1)+ETA(OCC_CL))

When this approach is used, OCC must be a data item defined in $INPUT.

Is there a similar way to code ETAs using a dynamic variable defined in $PK?

Thanks

Sebastien


Received on Tue Jan 15 2019 - 22:06:45 EST

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