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[NMusers] Job Opportunity at Merck Quantitative Pharmacology and Pharmacometrics

From: Gao, Wei (QP2, PPDM) <"Gao,>
Date: Mon, 7 Jan 2019 18:23:03 +0000

Dear Colleagues,

The department of Quantitative Pharmacology and Pharmacometrics (QP2) at Me=
rck is looking for a pharmacometrician to join our team. Please consider ap=
plying for the following Opening<

Senior Scientist/ Associate Principal Scientist, Quantitative Pharmacology =
and Pharmacometrics (QP2), Merck

Requisition ID: QUA008339

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United Sta=
tes and Canada, is a global health care leader with a diversified portfolio=
 of prescription medicines, vaccines and animal health products. The differ=
ence between potential and achievement lies in the spark that fuels innovat=
ion and inventiveness; this is the space where Merck has codified its legac=
y for over a century. Merck's success is backed by ethical integrity, forwa=
rd momentum, and an inspiring mission to achieve new milestones in global h=

Merck is on a quest for cures and is committed to being the world's premier=
, most research-intensive biopharmaceutical company. Today, we're doubling =
down on this goal. Merck Research Laboratories is a true scientific researc=
h facility of tomorrow, and will take Merck's leading discovery capabilitie=
s and world-class small molecule and biologics R&D expertise to create brea=
kthrough science that radically changes the way we approach serious disease=

Senior scientists in Quantitative Pharmacology and Pharmacometrics (QP2) ap=
ply quantitative approaches to develop and implement translational PK/PD st=
rategies, characterize clinical pharmacokinetics and pharmacodynamics of ne=
w chemical entities and biologics, and inform dose selection and go/no-go d=

Senior Scientists work in collaborative teams with more experienced scienti=
sts, and are expected to have or develop expertise in one or more areas nec=
essary to performing primary responsibilities including:

  * Being or supporting the lead representative for QP2 on drug/vaccine d=
evelopment teams
  * Data management and analysis
  * Framing critical drug development questions for optimizing model-base=
d development
  * Developing and executing translational PK/PD approaches, population p=
harmacokinetic models, exposure-response and stratification biomarker model=
s, quantitative system pharmacology (QSP) and disease progression models, c=
linical trial design via outcome/enrollment modeling and simulation, compar=
ator modeling, absorption/biopharmaceutical modeling, clinical utility inde=
x modeling, and other model-based analyses.

Senior Scientists are expected to develop a comprehensive understanding of =
global regulatory expectations for small molecules, biologics, and/or vacci=
nes, including support for regulatory documents (INDs, CSRs, CTDs), and age=
ncy interactions. The Senior Scientist is a proficient modeler, is able to =
develop a strong, integrated understanding of the strategic elements of dru=
g discovery and development, and contributes to or leads the combined effor=
ts of QP2 and the wider Department of Pharmacokinetics, Pharmacodynamics an=
d Drug Metabolism (PPDM).

Senior Scientists begin to develop leadership skills in areas such as mento=
ring, managing a program (while collaborating with QP2 Program Lead), proje=
ct, or initiative. In addition to the responsibilities outlined above, Seni=
or Scientists demonstrate good communication skills, collaborating within Q=
P2 and with other functional areas, as well as with external vendors and pa=
rtners, creating an aligned, quantitative framework to impact decisions of =
drug development teams.

Education Minimum Requirement:

* Master or equivalent degree with at least four years of experience, where=
 "experience" means having a record of increasing responsibility and indepe=
ndence in a similar role in pharmaceutical drug development or academia.

* Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at le=
ast two years of experience or an educational background in biopharmaceutic=
s, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biost=
atistics, computational biology/chemistry, chemical/biomedical engineering,=
 or a related field.

Required Experience and Skills**:

* Proficiency in R, Matlab, SAS, or other similar programing language

Preferred Experience and Skills:
* Experience in performing population PK / PKPD and non-compartmenta=
l analyses
* Experience with standard pharmacometric software (e.g. NONMEM, Mon=
olix, Phoenix, etc.)
* Skills in experimental design, mathematical problem solving, criti=
cal data analysis/interpretation, and statistics
* Scientific understanding of biopharmaceutical and ADME properties
* Proficiency in written and verbal communication, interdisciplinary=
 collaboration, and problem scoping and planning
 Your role at Merck is integral to helping the world meet new breakthroughs=
 that affect generations to come, and we're counting on your skills and inv=
entiveness to help make meaningful contributions to global medical advancem=
ent. At Merck, we're inventing for life.

If you need assistance and/or a reasonable accommodation due to a disabilit=
y during the application or the recruiting process, please send a request t=

Search Firm Representatives Please Read Carefully:
Merck & Co., Inc. is not accepting unsolicited assistance from search firms=
 for this employment opportunity. Please, no phone calls or emails. All r=
esumes submitted by search firms to any employee at Merck via email, the In=
ternet or in any form and/or method without a valid written search agreemen=
t in place for this position will be deemed the sole property of Merck. No=
 fee will be paid in the event the candidate is hired by Merck as a result =
of the referral or through other means.

For more information about personal rights under Equal Employment Opportuni=
ty, visit:

            EEOC Poster<
            EEOC GINA Supplement <
          OFCCP EEO Supplement<

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran =
- proudly embracing diversity in all of its manifestations.

Best Wishes,

Wei Gao, PhD
Quantitative Pharmacology & Pharmacometrics
Merck Research Laboratories
351 N Sumneytown Pike
North Wales, PA 19454

Notice: This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at = that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from =

your system.

Received on Mon Jan 07 2019 - 13:23:03 EST

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