NONMEM Users Network Archive

Hosted by Cognigen

REGISTRATION NOW Open - 1-day New & Advanced Features of NONMEM 7 Workshop - Presented by ICON Clinical Research - April 12 - Howard County Maryland

From: Wilhelm-Lear, Lisa <Lisa.Wilhelm>
Date: Thu, 21 Feb 2019 17:51:06 +0000

Presenters: Robert Bauer, PhD; Brian Sadler, PhD and Indrajit Das, PhD

Course Objectives:
The objective of this course is to introduce advanced concepts of population pharmacokinetics in NONMEM. The course is targeted to individuals interested in solving population PK/PD problems using the new stochastic methods. The course is for those who are familiar with classic NONMEM methods (first order (FO)/first order conditional estimation (FOCE)/Laplace), and are familiar with constructing control stream files. Most of the course is instructional, with several hands-on examples for attendee participation A thorough discussion of stochastic approximation expectation maximization (SAEM), Importance sampling (IMP), and Markov chain Monte Carlo Bayesian analysis (BAYES) will be presented, along with hands-on exercises. After attending this course, the participant will know how to use advanced stochastic methods for analyzing population PK/PD data; structure the models into a MU-referencing format that will greatly increase the efficiency of the analyses; apply prior information from previous analyses to the present data; create population mixture models; create models for categorical data; use new abbreviated code features for easier modeling of inter-occasion variability; model additional mixed effects levels for grouping individuals, such as inter-clinical site variability; use the new DO loop feature in abbreviated code, such as for handling multiple bolus doses in transit compartment models that use the analytical absorption function. Additional topics covered are: parallel computing and dynamic memory allocation for efficient memory usage; symbolic referencing to thetas, etas, and sigmas; Monte Carlo search algorithms to improve FOCE estimation; built-in individual weighted residuals; bootstrap tools for simulation; and greater control in average eta shrinkage calculations.
This course, the Beginners/Intermediate course, and the Modeling Delays course are part of one series. Interested parties may register for the first two days, the third day, the fourth day or any combination of the three courses.
The fees for the course are as follows:

Industry - $800/per day
Academia - $700/per day
Student - $600/per day
A discount of 15% is available to groups of 3 or more participants from the same organization.
Contact Lisa Wilhelm-Lear at Lisa.Wilhelm

Deadline for registration is: April 4, 2019

Lisa R. Wilhelm-Lear
Customer Service Lead
NONMEM / PDxPoP Software

Phone: 301-944-6771
Fax: 215-789-9549
Lisa.Wilhelm lto:Lisa.Wilhelm<>
<br /><br />
ICON plc made the following annotations.
This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you
are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If
you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message.

Thank You,

ICON plc
South County Business Park
Dublin 18
Registered number: 145835

Received on Thu Feb 21 2019 - 12:51:06 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: