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[NMusers] Different OBJ after covariance with parallel and IMPMAP

From: Mark Sale <>
Date: Mon, 4 Feb 2019 18:40:46 +0000

I've notices several times that when

using IMPMAP


Running parallel

the "one more iteration for variance" will fail on one (or more) of the pro=
cesses. When it does this, the OBJ will be lower than the last iteration of=

parameter estimation. It seems that when this happens, NONMEM uses the defa=
ult value (0) for OBJI for the data sent to that process, resulting in a lo=
wer OBJ. So, you can, in principle, rerun the model using the MSF and singl=
e process.

But, interestingly, while the OBJ reported in the outfile files seems to be=
 wrong, NONMEM will still report SEE etc. Can the SEE values in this case b=
e believed?

Mark Sale M.D.
Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713
Phone (919)-973-0383<>

Received on Mon Feb 04 2019 - 13:40:46 EST

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