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[NMusers] Lognormal survival in NONMEM?

From: Rik Schoemaker <rik.schoemaker_at_occams.com>
Date: Thu, 29 Aug 2019 13:33:02 +0000

Dear all,

Playing with repeated time to event models, I run into the issue that simpl=
e diagnostics for a single time to event outcome suggest that constant haza=
rd and Weibull models are not very appropriate. The lognormal model seems t=
o provide a very nice fit; compared to a constant hazard, the hazard is sug=
gested to be higher in the beginning and then significantly lower at later =
times.

I have not seen any implementations online: does anyone know if the lognorm=
al survival function can be implemented in NONMEM, and/or can anyone sugges=
t alternative approaches? Some time-varying function to modify the hazard?

Any and all suggestions appreciated!

Kind regards,

Rik



Rik Schoemaker, PhD
Occams Co÷peratie U.A.
Malandolaan 10
1187 HE Amstelveen
The Netherlands
www.occams.com<http://www.occams.com>
+31 20 441 6410
rik.schoemaker_at_occams.com<mailto:rik.schoemaker_at_occams.com>

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Received on Thu Aug 29 2019 - 09:33:02 EDT

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