NONMEM Users Network Archive

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PopPK modelling of DDIs

From: Pieter Colin <Pieter.Colin>
Date: Wed, 17 Apr 2019 12:24:42 +0000

Dear colleagues,

We are working on a model to describe a pharmacokinetic drug-drug interacti=
on between two drugs.
I recall that in the past there has been a discussion on the forum about si=
multaneously modelling two different drugs for the sake of sharing covariat=
es or covariate models between them.
Beyond those posts and a paper by van der Laan (AAC 2018) on a lopinavir-ri=
tonavir DDI, I cannot find published (coding) examples of how to approach D=
DIs in a joint PK model.
Hopefully some of you are willing to point us into the right direction?

Best regards,

Pieter Colin
Pharm.D., Ph.D.
Department of Anesthesiology (EB32)
University Medical Center Groningen, The Netherlands

Received on Wed Apr 17 2019 - 08:24:42 EDT

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