NONMEM Users Network Archive

Hosted by Cognigen

PBPK positions at Servier in France

From: marylore.chenel
Date: Mon, 24 Sep 2018 08:49:16 +0000

Servier is an international pharmaceutical company governed by a non-profit=
 Foundation and headquartered in France.
With a strong international presence in 148 countries and a turnover of 4 b=
illion euros in 2016, we employ over 21,000 people worldwide.
Being completely independent, we reinvest 25% of turnover (excluding generi=
cs) in Research and Development and use all our profits in growth.
We are specialized and driven by our constant search for innovation in five=
 major research areas: cardiovascular diseases, cancers, diabetes, immuno-i=
nflammatory diseases and neurodegenerative diseases, as well as by our acti=
vities in high-quality generic drugs.
Currently, we have 23 drug candidates including 19 new molecular entities a=
t various stages of clinical development.
Our priorities are pathologies with high medical needs within our areas of =

Company Strategy & 2020 Goals
- Increase Research output : launch on the market one new molecular en=
tity every 3 years
- Achieve sales of 5 billion Euros
- Become a key player in oncology and reinforce the group's presence i=
n its historical therapeutic areas, especially cardiology.


The Centre of Excellence in Pharmacokinetics (CentEx PK) at Servier has ope=
ning positions for Physiological Based PK modelling (PBPK) from Scientist t=
o Senior Principal Scientists.
The candidates will be full-time dedicated to modelling activities to suppo=
rt pre-clinical and clinical development programmes. The candidates will ha=
ve strong relationships with other modellers in pharmacometrics (i.e. early=
 phase and late phase popPK & PKPD modelling) and stakeholders within and o=
utside Servier (i.e. clinicians, pharmacologists, partners, CRO etc...).


The candidates will be responsible for:

· Defining the modelling strategy in collaboration with other pro=
ject members.

· PBPK model building and evaluation

· PBPK applications (simulations and extrapolation)

· Writing of Model building and Simulation plans, reports

· Presenting PBPK activities to internal/external experts in the =

According to his/her experience, the candidates will also participate to:

· The improvement of modelling tools and methodological developme=

· Junior mentoring in pharmacometrics

· Promotion of modelling activities within the Servier group

Skills and Experience

· PhD in a relevant area (PKPD/PBPK modeling, Biological Sciences=
, Pharmacology, Engineering, Pharmaceutical Sciences or other related disci=

· Good knowledge of PBPK software such as SimCYP, GastroPlus or P=
KSim. Knowledge in Matlab is an asset.

· Good communication and presentation skills. Fluent in English.

· Experience in applying PBPK concepts in drug development is an =
asset at the scientist level, and a minimum of 5 years is required at the p=
rincipal scientist level.

· Analytical mind-set and a strong desire to further develop and =
apply modelling and simulation in drug development.

The pharmacometrics group at Servier is located in France (2 sites: Suresne=
s near Paris and Orléans). Working knowledge of French is not a requireme=
You appreciate working in teams of scientists with different backgrounds an=
d the opportunity of expanding your network at an international level.
We offer an exciting opportunity for developing your professional skills an=
d for working with projects with many challenges and with support from a ra=
nge of highly skilled professionals.

For further information, please contact Marylore Chenel: marylore.chenel

Marylore CHENEL
Clinical Pharmacokinetics and Pharmacometrics
Mobile +33 (0)6 70 07 25 36 - Phone. +33 (0)1 55 72 38 56
50, rue Carnot 92284 - Suresnes, France<>

Received on Mon Sep 24 2018 - 04:49:16 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: