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[NMusers] NONMEM 2 Compartment Zero Order Absorption

From: Bishoy Hanna <bhanna_at_celgene.com>
Date: Mon, 1 Oct 2018 15:12:08 +0000

Hello all,


I am currently trying to model data for a compound that is orally administe=
red. A two compartment model with FIRST order oral absorption is not descri=
bing the data well (in my opinion). Consequently, I am attempting to model =
the data using the same two compartment model except with ZERO order absorp=
tion. I am under the impression that I am able to use ADVAN 4 TRANS 4 as we=
ll as a D1 = theta (1). I have included a rate = - 2 for my dosing reco=
rds in my data set.

My control stream is written as such:
$INPUT ID DOSE DAY TIME=TAD NTPD DV AMT COH ADDL II MDV RATE EVID CMT LDV
$SUBROUTINES ADVAN4 TRANS4
$PK
TVD1 = THETA(1)
D1 = TVD1*EXP(ETA(1))
TVCL=THETA(2)
CL=TVCL*EXP(ETA(2))
TVV2=THETA(3)
V2=TVV2*EXP(ETA(3))
TVQ = THETA(4)
Q=TVQ*EXP(ETA(4))
TVV3=THETA(5)
V3=TVV3*EXP(ETA(5))


However, I get the following error:

WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.

THE CHARACTERS IN ERROR ARE:
KA
196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.
NMtran failed. There is no output for model 1. Contents of FMSG:

WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
THE CHARACTERS IN ERROR ARE:
KA
196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.



My question is whether I can utilize ADVAN 4 TRANS 4 to model zero order ab=
sorption for an oral administered drug (if so, how do I address the error l=
isted above) OR if I have to utilize ADVAN 6?



Thanks in advance for taking time out of your busy day to help!

Regards,
Bishoy Hanna
Scientist
Celgene Corporation
179 Passaic Avenue, S11- 2645A, Summit, NJ, 07901
Phone: (908) 897 - 7733

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Received on Mon Oct 01 2018 - 11:12:08 EDT

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