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RE: Using Root-finding techniques to find Cmax/Tmax

From: Nick Holford <n.holford>
Date: Mon, 14 May 2018 16:54:25 +0000

Hi Bob,

Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge – I could barely understand a line of it.
Any chance you could zip up all the files into one archive file? I find myself faced with downloading a couple of pages of files one file at a time.

Best wishes,
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72
email: n.holford
Read the question, answer the question, attempt all questions

From: owner-nmusers m <owner-nmusers
Sent: Monday, May 14, 2018 5:55 PM
To: nmusers
Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax

Dear nmusers:
Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in

Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer Bauer<>

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Received on Mon May 14 2018 - 12:54:25 EDT

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