NONMEM Users Network Archive

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[NMusers] Advanced course on Pharmacometrics

From: roberto gomeni <roberto.gomeni_at_pharmacometrica.com>
Date: Thu, 21 Jun 2018 11:10:08 +0200

PharmacoMetrica is holding the:

 

10th Advanced course on Pharmacometrics

November 5-8, 2018: Chateau de Longcol (France)

 

This is a 3-day course designed to present advanced concepts on
pharmacometrics using novel methodologies based on integrated
drug-disease-trial models and surface response analysis. Case studies are
presented to illustrate how these tools can be used for improving the
decision-making process during drug development, for facilitating the
development and use of predictive models for describing complex PK profiles,
in-vitro/in-vivo correlation, and exposure-response relationships in
presence of confounding factors such as placebo effect and tolerance.

Course objectives

 

To present concepts and practical solutions for:

Advanced PK modeling

* To characterize the complex in-vivo absorption processes of
extended release formulations (ER) and Long Acting Injectable (LAI)
formulations using convolution-based approach

* To evaluate In-Vitro/In-Vivo correlation methods, including
convolution-deconvolution approach

 

Advanced exposure-response modeling

* To evaluate the relationship between drug exposure and clinical
response

* To develop models accounting for the confounding role of time
varying placebo response in the assessment of the clinical response

* To develop integrated disease-drug-trial models

* To handle acute tolerance effect

* To estimate the probability of clinical benefit of a treatment

 

Optimizing drug performances

* To implement drug optimization strategies using surface-response
analysis

* To determine the relationship between drug delivery and clinical
benefit

* To determine dose, dosage regimen and dosing strategies for
optimizing the clinical benefit

 

Course material

 

The R scripts (including Shiny based applications) used in the hands-on
sessions and the NONMEM control streams will be distributed to the
participants. The material includes:

 

o the convolution/deconvolution analysis,

o the clinical trial simulator for describing the clinical response in
presence of placebo and active drug response,

o the estimation of the optimal in-vitro dissolution profiles

o the convolution/deconvolution analysis,

o the non-linear optimizer used in the surface-response analysis

 

.

 

Venue: Chateau de Longcol (France): <http://www.chateadelongcol.com/>
http://www.chateadelongcol.com/

 

Additional details are available at:
<http://pharmacometricaworkshop.webs.com/>
http://pharmacometricaworkshop.webs.com/

 




Received on Thu Jun 21 2018 - 05:10:08 EDT

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