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Re: [NMusers] $ABBR REPLACE Limitations?

From: William Denney <wdenney_at_humanpredictions.com>
Date: Wed, 24 Jan 2018 07:08:26 -0500

Hi Bob,

Thanks for this confirmation. I'm using 7.4.1.

For my other question, is there a limitation of $ABBR REPLACE which prevents=
 its use for parameters like F1 and ALAG1?

Thanks,

Bill

> On Jan 24, 2018, at 00:43, Bauer, Robert <Robert.Bauer_at_iconplc.com> wrote:=

>
> This bug has been fixed since NONMEM 7.4
>
>
> Bug #1, nm730_bug_list.pdf in https://nonmem.iconplc.com/nonmem730
> Two variables with names longer than six characters, and identical in the f=
irst six characters, defined in $PK, and used in $DES, will be seen as the s=
ame variable. Use variable names that differ in the first six characters. T=
his occurs in NONMEM 7.1.0, 7.1.2, 7.2.0, and 7.3.0. A workaround is to mov=
e all assignment statements for variables whose first 6 characters match to $=
DES.
>
> Robert J. Bauer, Ph.D.
> Senior Director
> Pharmacometrics R&D
> ICON Early Phase
> 820 W. Diamond Avenue
> Suite 100
> Gaithersburg, MD 20878
> Office: (215) 616-6428
> Mobile: (925) 286-0769
> Robert.Bauer_at_iconplc.com
> www.iconplc.com
>
> From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] O=
n Behalf Of Bill Denney
> Sent: Tuesday, January 23, 2018 4:40 PM
> To: Luann Phillips
> Cc: nmusers
> Subject: RE: [NMusers] $ABBR REPLACE Limitations?
>
> Hi Luann,
>
> I’m not having similar problems with other parameters with >6 char=
acters. I had a similar issue with ALAG1, so I think that there are limitat=
ions on what types of variables you can remap. (Perhaps Allison or Bob coul=
d confirm?)
>
> Thanks,
>
> Bill
>
> From: Luann Phillips [mailto:luann_at_cognigencorp.com]
> Sent: Tuesday, January 23, 2018 3:51 PM
> To: Bill Denney <wdenney_at_humanpredictions.com>
> Cc: nmusers <nmusers_at_globomaxnm.com>
> Subject: Re: [NMusers] $ABBR REPLACE Limitations?
>
> Bill,
>
> I know at one time NM had a bug (haven't checked to see if it has been fix=
ed) that would cause variables with the first 6 characters the same to be in=
terpreted as the same variable even when later characters differed. I wonder=
 if this is a similar issue?
> Have you tried a shorter variable name, such as FCD1GUT=F1?
>
> Just a thought,
> Luann
>
> From: "Bill Denney" <wdenney_at_humanpredictions.com>
> To: "nmusers" <nmusers_at_globomaxnm.com>
> Sent: Tuesday, January 23, 2018 2:15:32 PM
> Subject: [NMusers] $ABBR REPLACE Limitations?
>
> Hi,
>
> I’m working in NONMEM 7.4.1 with a model where I need to track 4 d=
rugs simultaneously. To increase the model quality, I’m making heav=
y use of $ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I trac=
ed an issue with my model where there was no gradient on a bioavailability t=
erm to the fact that this substitution didn’t seem to be working:
>
> $ABBR REPLACE FCMTD1GUT=F1
> …
> $PK
> …
> FCMTD1GUT = THETA(1)
>
> FCMTD1GUT didn’t seem to be effectively replaced to F1, so the bio=
availability parameters had no effect. When I changed it to just directly n=
ame F1, it worked as expected.
>
> $PK
> …
> F1 = THETA(1)
>
> It’s not obvious from the $ABBR REPLACE section of the manual that=
 this is a limitation of $ABBR REPLACE. Is this an issue or am I missing so=
mething?
>
> Thanks,
>
> Bill
>
> <image001.jpg>William S. Denney, PhD
> Chief Scientist, Human Predictions LLC
> +1-617-899-8123
> wdenney_at_humanpredictions.com
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Received on Wed Jan 24 2018 - 07:08:26 EST

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