From: adrian.dunne

Date: Wed, 31 Jan 2018 15:40:43 -0000

TACA TRAINING <http://www.tacatraining.com> www.tacatraining.com

PHARMACOMETRIC STATISTICS

Registration is now open for this 3 day workshop to be held from 16th to

18th October (inclusive) 2018 in Dublin, Ireland.

The aim of this 3 day workshop is to give pharmacometricians a good

understanding of the statistical concepts upon which their work is based and

which are of great importance in everything they do. The emphasis will be on

concepts with an absolute minimum of mathematical details.

Attendees need only have studied statistics at foundation level prior to

taking this course.

The topics covered include;

1) Why use statistics?

2) Probability and statistical inference.

3) Laws of probability and Bayes theorem.

4) Univariate probability distributions - Expected value and variance.

5) Multivariate probability distributions - joint, marginal and conditional

distributions. The covariance matrix. Independence and conditional

independence.

6) Modelling, estimation, estimators, sampling distributions, bias,

efficiency, standard error and mean squared error. Consistency.

7) Point and interval estimators. Confidence intervals.

8) Hypothesis testing, null and alternative hypotheses. P-value, Type I and

Type II errors and power.

9) Likelihood inference, maximum likelihood estimator (MLE), likelihood

ratio. BQL and censored data.

10) Invariance of the likelihood ratio and the MLE.

11) The score function, hessian, Fisher information, quadratic approximation

and standard error.

12) Wald confidence intervals and hypothesis tests.

13) Likelihood ratio tests.

14) Profile likelihood, nested models.

15) Model selection, Akaike and Bayesian Information Criteria (AIC & BIC).

16) Maximising the likelihood, Newton's method.

17) Mixed effects models.

18) Estimation of the fixed effects, conditional independence, prior and

posterior distributions.

19) Approximating the integrals, Laplace and first order (FO & FOCE)

approximations, numerical quadrature.

20) The Expectation Maximisation (EM) algorithm.

21) MU-Modelling, Iterative Two Stage (ITS)

22) Monte Carlo EM (MCEM), Importance Sampling, Direct Sampling, SAEM,

Markov Chain Monte Carlo (MCMC).

23) Estimating the random effects, empirical bayes estimates (EBE) and

shrinkage.

24) Minimum Sufficiency, asymptotic properties of the MLE, efficiency, the

Cramer-Rao Lower Bound (CRLB), consistency, normality.

25) Robustness of the MLE, the Kullback-Liebler distance. Quasi likelihood

and the robust or sandwich variance estimator.

For further details and to register please go to our website

<http://www.tacatraining.com> www.tacatraining.com

Feedback from previous attendees is also available on our website.

Early registration is advised because the number of places is limited.

Adrian Dunne

Received on Wed Jan 31 2018 - 10:40:43 EST

Date: Wed, 31 Jan 2018 15:40:43 -0000

TACA TRAINING <http://www.tacatraining.com> www.tacatraining.com

PHARMACOMETRIC STATISTICS

Registration is now open for this 3 day workshop to be held from 16th to

18th October (inclusive) 2018 in Dublin, Ireland.

The aim of this 3 day workshop is to give pharmacometricians a good

understanding of the statistical concepts upon which their work is based and

which are of great importance in everything they do. The emphasis will be on

concepts with an absolute minimum of mathematical details.

Attendees need only have studied statistics at foundation level prior to

taking this course.

The topics covered include;

1) Why use statistics?

2) Probability and statistical inference.

3) Laws of probability and Bayes theorem.

4) Univariate probability distributions - Expected value and variance.

5) Multivariate probability distributions - joint, marginal and conditional

distributions. The covariance matrix. Independence and conditional

independence.

6) Modelling, estimation, estimators, sampling distributions, bias,

efficiency, standard error and mean squared error. Consistency.

7) Point and interval estimators. Confidence intervals.

8) Hypothesis testing, null and alternative hypotheses. P-value, Type I and

Type II errors and power.

9) Likelihood inference, maximum likelihood estimator (MLE), likelihood

ratio. BQL and censored data.

10) Invariance of the likelihood ratio and the MLE.

11) The score function, hessian, Fisher information, quadratic approximation

and standard error.

12) Wald confidence intervals and hypothesis tests.

13) Likelihood ratio tests.

14) Profile likelihood, nested models.

15) Model selection, Akaike and Bayesian Information Criteria (AIC & BIC).

16) Maximising the likelihood, Newton's method.

17) Mixed effects models.

18) Estimation of the fixed effects, conditional independence, prior and

posterior distributions.

19) Approximating the integrals, Laplace and first order (FO & FOCE)

approximations, numerical quadrature.

20) The Expectation Maximisation (EM) algorithm.

21) MU-Modelling, Iterative Two Stage (ITS)

22) Monte Carlo EM (MCEM), Importance Sampling, Direct Sampling, SAEM,

Markov Chain Monte Carlo (MCMC).

23) Estimating the random effects, empirical bayes estimates (EBE) and

shrinkage.

24) Minimum Sufficiency, asymptotic properties of the MLE, efficiency, the

Cramer-Rao Lower Bound (CRLB), consistency, normality.

25) Robustness of the MLE, the Kullback-Liebler distance. Quasi likelihood

and the robust or sandwich variance estimator.

For further details and to register please go to our website

<http://www.tacatraining.com> www.tacatraining.com

Feedback from previous attendees is also available on our website.

Early registration is advised because the number of places is limited.

Adrian Dunne

Received on Wed Jan 31 2018 - 10:40:43 EST