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RE: [NMusers] $ABBR REPLACE Limitations?

From: Bill Denney <wdenney_at_humanpredictions.com>
Date: Tue, 23 Jan 2018 19:40:28 -0500

Hi Luann,



I’m not having similar problems with other parameters with >6 chara=
cters.
I had a similar issue with ALAG1, so I think that there are limitations on
what types of variables you can remap. (Perhaps Allison or Bob could
confirm?)



Thanks,



Bill



*From:* Luann Phillips [mailto:luann_at_cognigencorp.com]
*Sent:* Tuesday, January 23, 2018 3:51 PM
*To:* Bill Denney <wdenney_at_humanpredictions.com>
*Cc:* nmusers <nmusers_at_globomaxnm.com>
*Subject:* Re: [NMusers] $ABBR REPLACE Limitations?



Bill,



I know at one time NM had a bug (haven't checked to see if it has been
fixed) that would cause variables with the first 6 characters the same to
be interpreted as the same variable even when later characters differed. I
wonder if this is a similar issue?

Have you tried a shorter variable name, such as FCD1GUT=F1?



Just a thought,

Luann


------------------------------

*From: *"Bill Denney" <wdenney_at_humanpredictions.com>
*To: *"nmusers" <nmusers_at_globomaxnm.com>
*Sent: *Tuesday, January 23, 2018 2:15:32 PM
*Subject: *[NMusers] $ABBR REPLACE Limitations?



Hi,



I’m working in NONMEM 7.4.1 with a model where I need to track 4 dr=
ugs
simultaneously. To increase the model quality, I’m making heavy us=
e of
$ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an
issue with my model where there was no gradient on a bioavailability term
to the fact that this substitution didn’t seem to be working:



$ABBR REPLACE FCMTD1GUT=F1



$PK



FCMTD1GUT = THETA(1)



FCMTD1GUT didn’t seem to be effectively replaced to F1, so the
bioavailability parameters had no effect. When I changed it to just
directly name F1, it worked as expected.



$PK



F1 = THETA(1)



It’s not obvious from the $ABBR REPLACE section of the manual that =
this is
a limitation of $ABBR REPLACE. Is this an issue or am I missing something?



Thanks,



Bill


------------------------------

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S. Denney, PhD*
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+1-617-899-8123
wdenney_at_humanpredictions.com

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Received on Tue Jan 23 2018 - 19:40:28 EST

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