NONMEM Users Network Archive

Hosted by Cognigen

Re: [NMusers] CMT Remapping

From: Leonid Gibiansky <lgibiansky_at_quantpharm.com>
Date: Tue, 23 Jan 2018 17:45:52 -0500

Hi Bill,

I do not think this is possible, but you are making things more
complicated than needed. You can slice the data set as needed using
IGNORE/ACCEPT options. For analytical ADVAN models, you often do not
need CMT item, and if needed, you can introduce extra columns CMT1,
CMT2, CMT3, and CMT4, for each of the 4 drugs, and CMTALL for the
combined model. So the only thing that would be needed is to re-code
parameter names and theta-eta-eps indices when you combine 4 models in
one. This step would be needed any way.

Best
Leonid




On 1/23/2018 2:26 PM, Bill Denney wrote:
> Hi,
>
> In a follow-up to the previous email, I’m still working on the same
> model where I need to track 4 drugs simultaneously.
>
> For this, I’m working from a single data file, and my initial modeling
> is drug 1 (first control stream), drug 2 (second control stream), drug 3
> (third control stream), drug 4 (fourth control stream).  As I progress
> through modeling, I intend to combine to a single control stream with
> all 4 drugs.
>
> I’d like to be able to speed up my modeling by taking advantage of the
> algebraic ADVAN/TRANS combinations while feasible, but I would also like
> to keep working within the same data file.  Is there any method to remap
> compartment numbers in a model file to an ADVAN-expected compartment?
> I’d like to do something like the following (which doesn’t work):
>
> $SUBROUTINES ADVAN4 TRANS4 CMTMAP=6,11,12,13
>
> Where CMTMAP would remap compartment number 6=1, 11=2, 12=3, and 13=4
> for the expected ADVAN numbering.
>
> Thanks,
>
> Bill
>
> ------------------------------------------------------------------------
>
> <http://www.humanpredictions.com>Human Predictions Logo
> <http://www.humanpredictions.com/><http://www.humanpredictions.com>*William
> S. Denney, PhD*
> Chief Scientist, Human Predictions LLC
> +1-617-899-8123
> wdenney_at_humanpredictions.com <mailto:wdenney_at_humanpredictions.com>
>
> This e-mail communication is confidential and is intended only for the
> individual(s) or entity named above and others who have been
> specifically authorized to receive it. If you are not the intended
> recipient, please do not read, copy, use or disclose the contents of
> this communication to others. Please notify the sender that you have
> received this e-mail in error by replying to the e-mail or by calling
> +1-617-899-8123. Please then delete the e-mail and any copies of it.
> Thank you.
>

Received on Tue Jan 23 2018 - 17:45:52 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request_at_iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.