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[NMusers] $ABBR REPLACE Limitations?

From: Bill Denney <wdenney_at_humanpredictions.com>
Date: Tue, 23 Jan 2018 14:15:32 -0500

Hi,



I’m working in NONMEM 7.4.1 with a model where I need to track 4 dr=
ugs
simultaneously. To increase the model quality, I’m making heavy us=
e of
$ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an
issue with my model where there was no gradient on a bioavailability term
to the fact that this substitution didn’t seem to be working:



$ABBR REPLACE FCMTD1GUT=F1



$PK



FCMTD1GUT = THETA(1)



FCMTD1GUT didn’t seem to be effectively replaced to F1, so the
bioavailability parameters had no effect. When I changed it to just
directly name F1, it worked as expected.



$PK



F1 = THETA(1)



It’s not obvious from the $ABBR REPLACE section of the manual that =
this is
a limitation of $ABBR REPLACE. Is this an issue or am I missing something?



Thanks,



Bill


------------------------------

<http://www.humanpredictions.com>[image: Human Predictions Logo]
<http://www.humanpredictions.com/> <http://www.humanpredictions.com>*Willia=
m
S. Denney, PhD*
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com

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Received on Tue Jan 23 2018 - 14:15:32 EST

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