NONMEM Users Network Archive

Hosted by Cognigen

RE: $ABBR REPLACE Limitations?

From: Bill Denney <wdenney>
Date: Tue, 23 Jan 2018 19:40:28 -0500

Hi Luann,

I’m not having similar problems with other parameters with >6 chara=
I had a similar issue with ALAG1, so I think that there are limitations on
what types of variables you can remap. (Perhaps Allison or Bob could



*From:* Luann Phillips [mailto:luann
*Sent:* Tuesday, January 23, 2018 3:51 PM
*To:* Bill Denney <wdenney
*Cc:* nmusers <nmusers
*Subject:* Re: [NMusers] $ABBR REPLACE Limitations?


I know at one time NM had a bug (haven't checked to see if it has been
fixed) that would cause variables with the first 6 characters the same to
be interpreted as the same variable even when later characters differed. I
wonder if this is a similar issue?

Have you tried a shorter variable name, such as FCD1GUT=F1?

Just a thought,



*From: *"Bill Denney" <wdenney
*To: *"nmusers" <nmusers
*Sent: *Tuesday, January 23, 2018 2:15:32 PM
*Subject: *[NMusers] $ABBR REPLACE Limitations?


I’m working in NONMEM 7.4.1 with a model where I need to track 4 dr=
simultaneously. To increase the model quality, I’m making heavy us=
e of
$ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an
issue with my model where there was no gradient on a bioavailability term
to the fact that this substitution didn’t seem to be working:




FCMTD1GUT didn’t seem to be effectively replaced to F1, so the
bioavailability parameters had no effect. When I changed it to just
directly name F1, it worked as expected.


F1 = THETA(1)

It’s not obvious from the $ABBR REPLACE section of the manual that =
this is
a limitation of $ABBR REPLACE. Is this an issue or am I missing something?




<>[image: Human Predictions Logo]
<> <>*Willi=
S. Denney, PhD*
Chief Scientist, Human Predictions LLC

This e-mail communication is confidential and is intended only for the
individual(s) or entity named above and others who have been specifically
authorized to receive it. If you are not the intended recipient, please do
not read, copy, use or disclose the contents of this communication to
others. Please notify the sender that you have received this e-mail in
error by replying to the e-mail or by calling +1-617-899-8123. Please then
delete the e-mail and any copies of it. Thank you.

Received on Tue Jan 23 2018 - 19:40:28 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: