NONMEM Users Network Archive

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Free Workshop

From: Matthew Riggs <riggsmm>
Date: Sat, 24 Feb 2018 12:43:14 +0000 (UTC)

Please join us at the University of Florida College of Pharmacy (Orlando Ca=
mpus) on Saturday March 24, 2018 (1:30-5:50 PM) for a free workshop: Case s=
tudies with mrgsolve: PBPK and QSP model implementation and utilization in =
In this tutorial session, we will review case studies in PBPK and QSP model=
ing and simulation using mrgsolve in R.  mrgsolve ( is a free, open-source modeling and simulation platform to support=
 ODE-based model development in R.
   - mrgsolve overview (brief tutorial)

   - PBPK model characterizing drug-drug interactions between HMG-CoA reduc=
tase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342) =

   - Sensitivity analyses

   - Parameter estimation

   - Evaluation of combination chemotherapy regimens using a QSP model for =
MAP kinase signaling in colorectal cancer (Kirouac et al. 2017; PMID 286494=

   - Create complicated input data sets

   - Options for parallelizing simulations
   - Discussion
Instructors: Kyle Baron Pharm.D., Ph.D., Matthew Riggs, Ph.D.
Materials Provided by Sponsor: Course slides, data and code for all example=
Requirements for Attendees: Knowledge and experience in population PKPD mod=
eling and a laptop with WiFi internet capability.
To register, please visit:

Received on Sat Feb 24 2018 - 07:43:14 EST

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