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The Passing of Alan Forrest

From: Dumond, Julie <jdumond>
Date: Thu, 30 Aug 2018 19:23:11 +0000

Dear NMUsers,

Please see below- sent on behalf of Dr. Angela Kashuba. I've pasted in the =
text of our memorial for Alan.

He wasn't a NONMEM user, but I know many of you knew and respected Alan. He=
 will be greatly missed by many, including me.



Alan Forrest, Pharm.D., 66, a clinical professor at the UNC Eshelman School=
 of Pharmacy and expert in pharmacokinetic and pharmacodynamics modeling, d=
ied Saturday, Aug. 25, at UNC Hospitals.

"Alan contributed to the field of pharmacokinetic and pharmacodynamic model=
ing for well over 30 years as a highly productive and innovative researcher=
 and an educator," said Dhiren Thakker, Ph.D., interim dean of the School. =
"He was world-renowned for his work on the use of quantitative approaches a=
nd mathematical modeling to optimize patient therapy, and he significantly =
impacted drug development and pharmacotherapy through his contributions in =
evolving the field of pharmacometrics. Alan will be sorely missed by his co=
lleagues in the School and around the world and by students who were his pa=

Internationally recognized as a leader in the field of pharmacometrics, For=
rest joined the School's Division of Pharmacotherapy and Experimental Thera=
peutics in 2015. In his career, he gave over 150 invited presentations, co-=
authored more than 500 peer-reviewed abstracts at national and internationa=
l scientific symposia and published more than 260 manuscripts with an H-ind=
ex of 50. His innovative research on quantitative approaches to optimize in=
dividual patient therapy, and on advanced applications of pharmacokinetic, =
pharmacodynamic and toxicodynamic systems analysis, has impacted drug devel=
opment and pharmacotherapy in significant ways. His research was directed p=
rimarily towards the pharmacology of anti-infective agents, but he also con=
tributed significantly to the development of optimal dosage regimens in the=
 treatment of cancer.

Forrest's pivotal paper linking ciprofloxacin exposures to clinical respons=
e in critically ill patients revolutionized antimicrobial drug development.=
 Because of this innovative research, pharmaceutical companies now regularl=
y conduct exposure response analyses for antimicrobials. More recently, For=
rest helped establish the current colistin dosing guidelines. In 2016, he w=
as recognized by the International Society of Pharmacometrics with the Lewi=
s B Sheiner Lecture Award, established to recognize outstanding life achiev=
ements in research or leadership in pharmacometrics.

"I was a student of Alan's in Buffalo and experienced first-hand his great =
love of teaching and mentoring students," said Angela Kashuba, Pharm.D., DP=
ET Chair and the John & Deborah McNeill, Jr. Distinguished Professor. "I wi=
ll miss him dearly, and I know all his colleagues around the world will mis=
s his work, his counsel and his friendship. Dr. Forrest leaves an incredibl=
e legacy through the many great scientists he trained."

Forrest was a world renowned pharmacometrician with great insight and exper=
tise for elegantly modeling complex systems. Through his research, he demon=
strated that modeling can enable the translation of new approaches into cli=
nical practice to improve the standard of care for patients. Forrest was re=
cognized widely as the expert on adaptive feedback control and individualiz=
ing therapy using novel models and methods for 'individual' and 'population=
' PK/PD systems analysis. He developed new tools to refine and optimize PK/=
PD study designs to maximize efficiency and enhance the information gained.=
 He also contributed significantly
to the development of new approaches to optimize outcomes in special patien=
t populations by integrating, linking and bridging data generated in vitro,=
 in preclinical models and in humans. Forrest also trained more than 100 st=
udents, fellows and visiting research scholars.

"Alan was one of the most dedicated and compassionate mentors I have known,=
" said Assistant Professor Gauri Rao, Pharm.D. "I worked with Alan as a pha=
rmacy student, fellow and junior faculty and realize that he lived life on =
his terms until the very end. Alan had endless amounts of energy and passio=
n when it came to work. He was very giving of his time, willing to spend ho=
urs to find the solution to a tough modeling problem or explaining a hard t=
o understand concept. He wanted to work
seven days a week and issues like school closing due to inclement weather o=
r a national holiday were irritants to him! Alan was worried that he had so=
 much more to contribute and so little time."

Forrest received his Pharm.D. from the University of Southern California in=
 1979. He completed a postdoctoral fellowship in clinical pharmacology at t=
he USC School of Medicine's Laboratory of Applied Pharmacokinetics under th=
e mentorship of Roger Jeliffe, M.D. Forrest held appointments at USC and th=
e University of Maryland at Baltimore before joining the University of Buff=
alo faculty as director of pharmacometrics and biostatistical analysis in t=
he Department of Pharmacy Practice at the UB School of Pharmacy in 1990. He=
 also held an appointment as a research professor in the Department of Phar=
macy Practice and in the Department of Biostatistics of the UB School of Pu=
blic Health. He served as the senior director of pharmacometrics at the Ins=
titute for Clinical Pharmacodynamics in Latham, New York. Since 1997, Forre=
st also worked as an expert adviser in pharmacokinetics and pharmacodynamic=
s to the Food and Drug Administration in Silver Spring, Maryland.

Condolences can be sent to the family via Amherst Memorial Chapel in Buffal=
o, New York.

From: Kashuba, Angela D
Sent: Wednesday, August 29, 2018 12:15 PM
To: Sharon Swan <sharon; pkpd
Cc: Rao, Gauri <gaurirao
Subject: The Passing of Alan Forrest

Dear Colleagues;

It is with deep sadness that I inform you of Alan Forrest's passing on Satu=
rday. I know this news has travelled quickly around the globe, but I wante=
d to provide you with UNC's memorial regarding Alan. Please feel free to d=
istribute as you see fit.

All the best,

Angela DM Kashuba, BScPhm, PharmD, DABCP, FCP
John A. and Deborah S. McNeill Jr. Distinguished Professor
Chair, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman =
School of Pharmacy,
Director, Clinical Pharmacology and Analytical Chemistry Core, UNC Center f=
or AIDS Research
Adjunct Professor of Medicine, UNC School of Medicine, Division of Infectio=
us Diseases,
1094 Genetic Medicine Building, CB# 7361
120 Mason Farm Road
University of North Carolina at Chapel Hill Chapel Hill, NC 27599-7569
TEL: (919) 966-9998 FAX: (919) 966-1020
EMAIL: akashuba

Received on Thu Aug 30 2018 - 15:23:11 EDT

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