NONMEM Users Network Archive

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10th Advanced course on Pharmacometrics

From: roberto gomeni <roberto.gomeni>
Date: Tue, 28 Aug 2018 15:18:42 +0200

Dear Members,


Don't miss this exciting opportunity to learn novel pharmacometrics
approaches for improving the efficiency of drug development.


PharmacoMetrica is holding the:


10th Advanced course on Pharmacometrics

November 5-8, 2018: Chateau de Longcol (France)


This is a 3-day course designed to present advanced concepts on
pharmacometrics using novel methodologies based on integrated
drug-disease-trial models, surface response analysis and clinical trial
simulation. Case studies are presented to illustrate how these tools can be
used for improving the decision-making process during drug development, for
facilitating the development and use of predictive models for describing
complex PK profiles, in-vitro/in-vivo correlation, and exposure-response
relationships in presence of confounding factors such as placebo effect and


Course objectives


To present concepts and practical solutions for:


Advanced PK modeling

* To characterize the complex in-vivo absorption processes of
extended release formulations (ER) and Long Acting Injectable (LAI)
formulations using convolution-based approach

* To evaluate In-Vitro/In-Vivo correlation methods, including
convolution-deconvolution approach


Advanced exposure-response modeling

* To evaluate the relationship between drug exposure and clinical

* To develop models accounting for the confounding role of time
varying placebo response in the assessment of the clinical response

* To develop integrated disease-drug-trial models

* To handle acute tolerance effect

* To estimate the probability of clinical benefit of a treatment


Optimizing drug performances

* To implement drug optimization strategies using surface-response

* To determine the relationship between drug delivery and clinical

* To determine dose, dosage regimen and dosing strategies for
optimizing the clinical benefit


Course material


The R scripts (including Shiny based applications) used in the hands-on
sessions and the NONMEM control streams will be distributed to the
participants. The material includes:


o the convolution/deconvolution analysis,

o the clinical trial simulator for describing the clinical response in
presence of placebo and active drug response,

o the estimation of the optimal in-vitro dissolution profiles

o the convolution/deconvolution analysis,

o the non-linear optimizer used in the surface-response analysis


Venue: Chateau de Longcol (France): <>


Additional details are available at:


Roberto Gomeni, PhD


Longcol, 12270 La Fouillade (France)


Next workshop: <>


Received on Tue Aug 28 2018 - 09:18:42 EDT

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