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New position at Nektar Therapeutics: Associate Director of Pharmacometrics

From: Gordi, Toufigh <TGordi>
Date: Wed, 20 Sep 2017 23:52:20 +0000

Position Summary:
Nektar Therapeutics is seeking an experienced pharmacometrician to join the=
 company at the Associate Director (AD) level. The position is in the pharm=
acometric group, a part of the clinical pharmacology department, and the ne=
w AD will work closely with other modelers and non-modelers to advance drug=
 candidates from preclinical to late clinical phases by applying a model-ba=
sed drug development paradigm.

Nektar Therapeutics continues to advance a model-based drug development par=
adigm throughout the organization. The current position offers an exciting =
opportunity to be a contributing part of the company's efforts in promoting=
 quantitative analysis techniques at all stages of drug development. We off=
er a highly collaborative and scientific environment and the opportunity to=
 shape the future of the company's path toward a more effective and model-b=
ased drug development process.

Help apply quantitative analysis methods and PK/PD modeling techniques in d=
eveloping candidate drug products from preclinical through Phase III. Serve=
 as an expert to all relevant disciplines and ensure that modeling and simu=
lation (M&S) methods are used optimally in discovery and development activi=
ties. Plan and execute PK/PD M&S activities in the design and analysis of =
in vivo and in vitro studies working with a multidisciplinary team. Repres=
ent clinical pharmacology/quantitative analysis in project team meetings, c=
ollaborating with others on the principles and theories of quantitative eva=
luation of new products. In collaboration with other members of the team m=
ake decisions impacting PK/PD analysis goals and the success and relevance =
of individual preclinical and clinical studies. Contribute to the design a=
nd preparation of preclinical and clinical pharmacokinetics development str=
ategies and study protocols, performing and supervising pharmacokinetic and=
 pharmacodynamic analyses, and preparation of clinical study reports and in=
tegrated summary documents. Provide feedback and direction for regulatory =
submissions preparation and review support for new or existing products. W=
ork closely with clinical operations, biostatistics, data management, resea=
rch, drug metabolism, and therapeutics areas. Help oversee and maintain Ne=
ktar's storage of pharmacometric files and archive system. Contribute to th=
e development and implementation of SOPs within the Pharmacometrics group. =
Provide scientific/technical guidance, leadership, and decision-making as a=
ppropriate. Provide regular performance feedback, development, and coaching=
 to direct reports, if any.

A minimum of PhD in pharmacokinetics/pharmacodynamics or pharmacometrics is=
 required. Other relevant backgrounds may be considered. A minimum of 8 yea=
rs of experience in designing, analyzing, and reporting nonclinical and cli=
nical drug development studies is required. Equivalent experience may be ac=
cepted. Must be proficient in creation and management of datasets and in us=
e of major PK/PD software such as WinNonlin, Monolix, and NONMEM and have w=
orking knowledge of software used to create graphical output and report stu=
dy results. Strong written and verbal communication skills are required; mu=
st be able to independently create high quality written reports and summary=
 documents for use in regulatory submissions. Desire to work in a cross-fun=
ctional drug development team environment with all levels of employees and =
management is valued. Must be goal-oriented, quality-conscientious, and pro=
ject-focused, with demonstrated ability to develop successful influential r=
elationships with colleagues, both internal and external. Understand how to=
 set expectations and negotiate proper milestones to track progress.

Those interested in the position can contact me directly.


Toufigh Gordi, PhD, MBA
Senior Director of Pharmacometrics
Nektar Therapeutics
Tel.: 415-482-5306
Email: tgordi

Received on Wed Sep 20 2017 - 19:52:20 EDT

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