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[NMusers] Pred-corrected VPC with bounded data

From: Matts Kågedal <mattskagedal_at_gmail.com>
Date: Thu, 7 Sep 2017 10:38:10 -0700

Dear modelers,

Working on a model where the observations are bound between 0 and 100.
Using logit transformation in the model to account for this (I dont
transform the data).

Would like to assess the model based on a VPC.
Since dosing is per the physicians decision based on the observed response,
I would like to generate a pred-corrected VPC using PsN.

When reading the PsN userguide, it says that "*The predcorr feature will
not work well if there is an upper bound, e.g. when the dependent variable
is logit transformed."*

Any thoughts on how to solve this would be appreciated. Would ideally like
to avoid having to simulated the physicians dose decisions.

Best,
Matts Kagedal
Genentech


Received on Thu Sep 07 2017 - 13:38:10 EDT

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