NONMEM Users Network Archive

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Modelling 2-level IOV

From: Mo Sora <soramo12>
Date: Wed, 14 Jun 2017 12:11:43 +0200

Dear NMusers,

I have a question regarding IOV modelling.

I have a cohort of patients to whom a drug is given on 3 days consecutive
for 3 cycles (with 21-day interval). Blood samples are taken on each of the
3 days whithin each cycle. I would like to know if there is a way to code
simultaneously the inter-day and inter-cycle variability of any PK
parameter of interest (Clearance in our study). In other words, a way to
have two levels of IOV ?

Thanks a lot for any answers or suggestions!

Warm regards,

Sotheara MOEUNG

Received on Wed Jun 14 2017 - 06:11:43 EDT

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