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Re: Inherit past calculation of parameter in NONMEM

From: Nick Holford <n.holford>
Date: Wed, 14 Jun 2017 12:04:48 +0200


You can "remember" the value of any variable created in NM-TRAN
abbreviated code. You have to be careful if the variable is a random
effect to always include the else case.



CLLAST=? ; some plausible initial value








Best wishes,

On 14-Jun-17 11:35, Guo, Tingjie wrote:
> Dear NMusers,
> Maybe a simple question. I was wondering if there is such
> functionality in NONMEM to inherit the past (e.g. previous row) value
> of parameter calculated with time varying covariates? For instance,
> the CL was determined by a time varying covariate. Calculation CL was
> a negative number in time record 3 due to the covariate value at that
> time point. I would like to use calculation CL in time record 2 as
> instead for time record 3. Pseudocode is somewhat like *IF
> (CL[i].LE.0) CL[i]=CL[i-1]*. Is this possible to implement within
> NONMEM? Thanks in advance.
> Warm regards,
> Tingjie
> *Tingjie Guo I Trainee Research Assistant *
> Academic Medical Centre, University of Amsterdam.
> VU University Medical Centre, Vrije University Amsterdam.
> Room ZH-7D-172, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
> Email: t.guo
> <mailto:t.guo

Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72
email: n.holford
Read the question, answer the question, attempt all questions

Received on Wed Jun 14 2017 - 06:04:48 EDT

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