NONMEM Users Network Archive

Hosted by Cognigen

[NMusers] Interesting vacancy for a PhD candidate

From: <D.J.A.R.Moes_at_lumc.nl>
Date: Tue, 18 Jul 2017 09:43:26 +0000

Dear All,

We have an open vacancy for a PhD candidate:

As PhD student in the Department of Clinical Pharmacy and Toxicology, you w=
ill be involved in the innovative research line 'Targeted therapy and clona=
l evolution of heterogeneous tumors.' Specific treatment of cancer is incre=
asingly chosen on the basis of the presence of specific somatic mutations o=
r protein expression in the tumor. Due to tumor heterogeneity and clonal ev=
olution this is a very dynamic process. For this reason, the most optimal t=
argeted drug may change over time. The goal of this new research line is to=
 develop and apply systems pharmacology models to predict the most optimal =
therapy for individual patients.
The project focuses on the mathematical description of and ultimately predi=
ction of tumor growth and tumor clone development during treatment of oncol=
ogical and hematological diseases using targeted therapies such as tyrosine=
 kinase inhibitors. Data concerning pharmacokinetics, pharmacodynamics (tum=
or growth and heterogeneity) and drug sensitivity will be combined to devel=
op models for predicting the most optimal therapy for the individual patien=
t in the future. The research will involve several pharmacometric software =
systems for PK/PD and systems pharmacology modelling such as NONMEM, PKSim =
and Mobi. This research will be performed in close collaboration with diffe=
rent departments that participate in the Leiden Network for Personalised Th=
erapeutics (www.lnpt.nl<https://www.lumc.nl/org/lnpt/>).

For more info about the vacancy see the link below:

https://www.lumc.nl/over-het-lumc/werken-bij/vacatures-solliciteren/researc=
h-onderwijs/Onderzoeker-in-Opleiding-(OIO)-KFT?setlanguage=English&setcou=
ntry=en

Best Regards,

Dirk Jan Moes

Dr. D.J.A.R. Moes, PharmD, PhD | Hospital Pharmacist Laboratory (TDM/Toxico=
logy) / Pharmacometrician
Leiden University Medical Center | Department of Clinical Pharmacy and Toxi=
cology
Contact: pGSM: +31715297960 | Mobile: +31643052862 | Email: D.J.A.R.Moes_at_lu=
mc.nl<mailto:D.J.A.R.Moes_at_lumc.nl>
Fax: +31715266106 | Visitors: Albinusdreef 2, Room: L1-13, 2333 ZA, Leiden,=
 The Netherlands
Regular mail: PO box: 9600, 2300 RC, Leiden, The Netherlands



Received on Tue Jul 18 2017 - 05:43:26 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.