NONMEM Users Network Archive

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RE: [NMusers] Objective function

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Mon, 16 Jan 2017 17:12:42 +0000

Sebastien:
All methods in NONMEM are -2LL based.

Robert J. Bauer, Ph.D.
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com
www.iconplc.com

-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of sbihorel
Sent: Monday, January 16, 2017 3:13 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Objective function

Hi,

This might appear like a very naive question but I could not find the information in the NONMEM use guide: what is the value of the objective function for ITS, IMP, SAEM, and BAYES estimation methods in relation to the log likelihood? Is it the standard minus 2 times the log likelihood like for FO, FOCE, FOCEI, or LAPLACE methods?

Thank you

Sebastien
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Received on Mon Jan 16 2017 - 12:12:42 EST

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